Detailed information of TA system TA130391

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3690393..3691067
• Replicon: chromosome
• Accession: NZ_CP041806
• Organism: Mycobacterium tuberculosis strain SEA11020057P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P9WF52
• Locus tag: FPK03_RS17315
• Protein ID: WP_003417282.1
• Coordinates: 3690393..3690821 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TI59
• Locus tag: FPK03_RS17320
• Protein ID: WP_003417286.1
• Coordinates: 3690825..3691067 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPK03_RS17290	3686215..3686616	-	402	WP_003417264.1	cytidine deaminase	-
FPK03_RS17295	3686757..3687191	+	435	WP_003900017.1	succinate dehydrogenase, cytochrome b556 subunit	-
FPK03_RS17300	3687188..3687622	+	435	WP_003913036.1	succinate dehydrogenase hydrophobic membrane anchor subunit	-
FPK03_RS17305	3687751..3689523	+	1773	WP_003417273.1	succinate dehydrogenase flavoprotein subunit	-
FPK03_RS17310	3689523..3690314	+	792	WP_057155080.1	succinate dehydrogenase iron-sulfur subunit	-
FPK03_RS17315	3690393..3690821	-	429	WP_003417282.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPK03_RS17320	3690825..3691067	-	243	WP_003417286.1	ribbon-helix-helix domain-containing protein	Antitoxin
FPK03_RS17325	3691189..3691803	-	615	WP_003417288.1	class I SAM-dependent methyltransferase	-
FPK03_RS17330	3691800..3692465	-	666	WP_003417290.1	molybdopterin converting factor subunit 1	-
FPK03_RS17335	3692466..3692999	-	534	WP_003417293.1	cyclic pyranopterin monophosphate synthase MoaC	-
FPK03_RS17340	3692996..3693370	-	375	WP_003417295.1	4a-hydroxytetrahydrobiopterin dehydratase	-
FPK03_RS17345	3693467..3694531	-	1065	WP_003913037.1	GTP 3',8-cyclase MoaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-141)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15834.16 Da
• Isoelectric Point: 8.5471

>T130391 WP_003417282.1 NZ_CP041806:c3690821-3690393 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Nucleotide

• Length: 429 bp

>T130391 NZ_CP041806:c3690821-3690393 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8849.86 Da
• Isoelectric Point: 5.1007

>AT130391 WP_003417286.1 NZ_CP041806:c3691067-3690825 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Nucleotide

• Length: 243 bp

>AT130391 NZ_CP041806:c3691067-3690825 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Structures

Toxin

• AlphaFold DB: A0A7U4FBL0

Antitoxin

• AlphaFold DB: G0TI59