Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2916909..2917623 Replicon chromosome
Accession NZ_CP041806
Organism Mycobacterium tuberculosis strain SEA11020057P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag FPK03_RS13550 Protein ID WP_003413460.1
Coordinates 2917183..2917623 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag FPK03_RS13545 Protein ID WP_003413456.1
Coordinates 2916909..2917196 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK03_RS13510 2912331..2912576 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
FPK03_RS13515 2912573..2912977 + 405 WP_003899389.1 type II toxin-antitoxin system VapC family toxin -
FPK03_RS13520 2913194..2913814 + 621 WP_003912795.1 DUF4178 domain-containing protein -
FPK03_RS13525 2913825..2914319 + 495 WP_003413444.1 DUF2617 family protein -
FPK03_RS13530 2914316..2914747 + 432 WP_003899390.1 DUF4247 domain-containing protein -
FPK03_RS13535 2914772..2915230 + 459 WP_003413451.1 DUF350 domain-containing protein -
FPK03_RS13540 2915227..2916798 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
FPK03_RS13545 2916909..2917196 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
FPK03_RS13550 2917183..2917623 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
FPK03_RS13555 2917644..2918399 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
FPK03_RS13560 2918532..2919128 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
FPK03_RS13565 2919136..2919981 - 846 WP_003413466.1 acyl-CoA thioesterase II -
FPK03_RS13570 2920010..2920909 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
FPK03_RS13575 2921037..2921711 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T130382 WP_003413460.1 NZ_CP041806:2917183-2917623 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T130382 NZ_CP041806:2917183-2917623 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT130382 WP_003413456.1 NZ_CP041806:2916909-2917196 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT130382 NZ_CP041806:2916909-2917196 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References