Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
| Location | 2854994..2855703 | Replicon | chromosome |
| Accession | NZ_CP041806 | ||
| Organism | Mycobacterium tuberculosis strain SEA11020057P6C4 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | FPK03_RS13265 | Protein ID | WP_003912787.1 |
| Coordinates | 2854994..2855407 (+) | Length | 138 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | P95006 |
| Locus tag | FPK03_RS13270 | Protein ID | WP_003413167.1 |
| Coordinates | 2855446..2855703 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FPK03_RS13235 | 2850047..2851252 | - | 1206 | WP_003413027.1 | chorismate synthase | - |
| FPK03_RS13240 | 2851360..2851674 | + | 315 | WP_009937839.1 | hypothetical protein | - |
| FPK03_RS13245 | 2851970..2853181 | + | 1212 | WP_003900845.1 | alpha/beta hydrolase family protein | - |
| FPK03_RS13250 | 2853308..2853967 | + | 660 | WP_003900846.1 | LppA family lipoprotein | - |
| FPK03_RS13255 | 2853964..2854626 | + | 663 | WP_003900848.1 | hypothetical protein | - |
| FPK03_RS13260 | 2854623..2854901 | + | 279 | WP_003901422.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| FPK03_RS13265 | 2854994..2855407 | + | 414 | WP_003912787.1 | PIN domain nuclease | Toxin |
| FPK03_RS13270 | 2855446..2855703 | + | 258 | WP_003413167.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| FPK03_RS13275 | 2855700..2856077 | + | 378 | WP_003413174.1 | type II toxin-antitoxin system VapC family toxin | - |
| FPK03_RS13280 | 2856093..2856467 | - | 375 | WP_003413177.1 | hypothetical protein | - |
| FPK03_RS13285 | 2856567..2856962 | - | 396 | WP_003413180.1 | type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 | - |
| FPK03_RS13290 | 2856959..2857204 | - | 246 | WP_003413183.1 | type II toxin-antitoxin system antitoxin VapB20 | - |
| FPK03_RS13295 | 2857615..2858034 | - | 420 | WP_003413190.1 | A24 family peptidase | - |
| FPK03_RS13300 | 2858046..2858855 | - | 810 | WP_003413193.1 | shikimate dehydrogenase | - |
| FPK03_RS13305 | 2858852..2860105 | - | 1254 | WP_003413196.1 | endolytic transglycosylase MltG | - |
| FPK03_RS13310 | 2860098..2860610 | - | 513 | WP_003413197.1 | Holliday junction resolvase RuvX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 138 a.a. Molecular weight: 15044.06 Da Isoelectric Point: 6.1243
>T130379 WP_003912787.1 NZ_CP041806:2854994-2855407 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAKTFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAKTFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL
Download Length: 414 bp
>T130379 NZ_CP041806:2854994-2855407 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCAAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCAAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9453.63 Da Isoelectric Point: 10.6555
>AT130379 WP_003413167.1 NZ_CP041806:2855446-2855703 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
Download Length: 258 bp
>AT130379 NZ_CP041806:2855446-2855703 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|