Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2867507..2868144 Replicon chromosome
Accession NZ_CP041805
Organism Mycobacterium tuberculosis strain SEA11020068P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P0DMV7
Locus tag FPK04_RS13305 Protein ID WP_003413180.1
Coordinates 2867507..2867902 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ44
Locus tag FPK04_RS13310 Protein ID WP_003413183.1
Coordinates 2867899..2868144 (-) Length 82 a.a.

Genomic Context

FPK04_RS13265FPK04_RS13270FPK04_RS13275FPK04_RS13280FPK04_RS13285FPK04_RS13290FPK04_RS13295FPK04_RS13300FPK04_RS13305FPK04_RS13310FPK04_RS13315FPK04_RS13320FPK04_RS13325FPK04_RS13330
Location: 2863592..2864251 (660 bp)
Type: Others
Protein ID: WP_003900846.1
Location: 2864248..2864907 (660 bp)
Type: Others
Protein ID: WP_003900847.1
Location: 2864904..2865566 (663 bp)
Type: Others
Protein ID: WP_003900848.1
Location: 2865563..2865841 (279 bp)
Type: Others
Protein ID: WP_003901422.1
Location: 2865934..2866347 (414 bp)
Type: Others
Protein ID: WP_003413164.1
Location: 2866386..2866643 (258 bp)
Type: Others
Protein ID: WP_003413167.1
Location: 2866640..2867017 (378 bp)
Type: Others
Protein ID: WP_003413174.1
Location: 2867033..2867407 (375 bp)
Type: Others
Protein ID: WP_003413177.1
Location: 2867507..2867902 (396 bp)
Type: Toxin
Protein ID: WP_003413180.1
Location: 2867899..2868144 (246 bp)
Type: Antitoxin
Protein ID: WP_003413183.1
Location: 2868555..2868974 (420 bp)
Type: Others
Protein ID: WP_003413190.1
Location: 2868986..2869795 (810 bp)
Type: Others
Protein ID: WP_003413193.1
Location: 2869792..2871045 (1254 bp)
Type: Others
Protein ID: WP_003413196.1
Location: 2871038..2871550 (513 bp)
Type: Others
Protein ID: WP_003413197.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FPK04_RS132652863592..2864251+660WP_003900846.1LppA family lipoprotein-
FPK04_RS132702864248..2864907+660WP_003900847.1hypothetical protein-
FPK04_RS132752864904..2865566+663WP_003900848.1hypothetical protein-
FPK04_RS132802865563..2865841+279WP_003901422.1type II toxin-antitoxin system VapB family antitoxin-
FPK04_RS132852865934..2866347+414WP_003413164.1PIN domain nuclease-
FPK04_RS132902866386..2866643+258WP_003413167.1ribbon-helix-helix domain-containing protein-
FPK04_RS132952866640..2867017+378WP_003413174.1type II toxin-antitoxin system VapC family toxin-
FPK04_RS133002867033..2867407-375WP_003413177.1hypothetical protein-
FPK04_RS133052867507..2867902-396WP_003413180.1type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20Toxin
FPK04_RS133102867899..2868144-246WP_003413183.1type II toxin-antitoxin system antitoxin VapB20Antitoxin
FPK04_RS133152868555..2868974-420WP_003413190.1A24 family peptidase-
FPK04_RS133202868986..2869795-810WP_003413193.1shikimate dehydrogenase-
FPK04_RS133252869792..2871045-1254WP_003413196.1endolytic transglycosylase MltG-
FPK04_RS133302871038..2871550-513WP_003413197.1Holliday junction resolvase RuvX-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endonuclease VapC20-like

(1-129)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14619.53 Da        Isoelectric Point: 6.9794

>T130320 WP_003413180.1 NZ_CP041805:c2867902-2867507 [Mycobacterium tuberculosis]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE

Download         Length: 396 bp

>T130320 NZ_CP041805:c2867902-2867507 [Mycobacterium tuberculosis]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9098.33 Da        Isoelectric Point: 5.6007

>AT130320 WP_003413183.1 NZ_CP041805:c2868144-2867899 [Mycobacterium tuberculosis]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E

Download         Length: 246 bp

>AT130320 NZ_CP041805:c2868144-2867899 [Mycobacterium tuberculosis]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB5WZ4
PDB5WZF

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7U4BW31

References