Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2366180..2366875 Replicon chromosome
Accession NZ_CP041805
Organism Mycobacterium tuberculosis strain SEA11020068P6C4

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag FPK04_RS10940 Protein ID WP_003410811.1
Coordinates 2366180..2366614 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag FPK04_RS10945 Protein ID WP_003410814.1
Coordinates 2366621..2366875 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK04_RS10925 2362369..2363907 + 1539 WP_023637436.1 HNH endonuclease -
FPK04_RS10930 2364106..2365776 + 1671 Protein_2161 ATP-dependent helicase -
FPK04_RS10935 2365779..2366201 + 423 Protein_2162 SWIM zinc finger family protein -
FPK04_RS10940 2366180..2366614 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
FPK04_RS10945 2366621..2366875 - 255 WP_003410814.1 antitoxin Antitoxin
FPK04_RS10950 2366891..2367148 - 258 WP_003410816.1 hypothetical protein -
FPK04_RS10955 2368095..2368391 + 297 WP_003410820.1 PE family protein -
FPK04_RS10960 2368447..2369178 + 732 WP_003900467.1 PPE family protein -
FPK04_RS10965 2369718..2370464 - 747 WP_003899174.1 proteasome subunit alpha -
FPK04_RS10970 2370461..2371336 - 876 WP_003411023.1 proteasome subunit beta -
FPK04_RS10975 2371333..2371527 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T130314 WP_003410811.1 NZ_CP041805:c2366614-2366180 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T130314 NZ_CP041805:c2366614-2366180 [Mycobacterium tuberculosis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT130314 WP_003410814.1 NZ_CP041805:c2366875-2366621 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT130314 NZ_CP041805:c2366875-2366621 [Mycobacterium tuberculosis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References