Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2233118..2233704 Replicon chromosome
Accession NZ_CP041805
Organism Mycobacterium tuberculosis strain SEA11020068P6C4

Toxin (Protein)


Gene name mazF Uniprot ID G0TLY3
Locus tag FPK04_RS10360 Protein ID WP_003410010.1
Coordinates 2233118..2233462 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL58
Locus tag FPK04_RS10365 Protein ID WP_003410014.1
Coordinates 2233456..2233704 (-) Length 83 a.a.

Genomic Context

FPK04_RS10325FPK04_RS10330FPK04_RS10335FPK04_RS10350FPK04_RS10385FPK04_RS10340FPK04_RS10345FPK04_RS10355FPK04_RS10360FPK04_RS10365FPK04_RS10370FPK04_RS10375FPK04_RS10380
Location: 2228824..2229423 (600 bp)
Type: Others
Protein ID: WP_003409989.1
Location: 2229839..2230267 (429 bp)
Type: Others
Protein ID: WP_003409992.1
Location: 2230493..2231032 (540 bp)
Type: Others
Protein ID: WP_003900446.1
Location: 2232536..2232793 (258 bp)
Type: Others
Protein ID: WP_003410006.1
Location: 2236945..2237712 (768 bp)
Type: Others
Protein ID: WP_003900447.1
Location: 2231552..2232112 (561 bp)
Type: Others
Protein ID: WP_003410001.1
Location: 2232109..2232450 (342 bp)
Type: Others
Protein ID: WP_003410003.1
Location: 2232694..2233029 (336 bp)
Type: Others
Protein ID: WP_003410009.1
Location: 2233118..2233462 (345 bp)
Type: Toxin
Protein ID: WP_003410010.1
Location: 2233456..2233704 (249 bp)
Type: Antitoxin
Protein ID: WP_003410014.1
Location: 2233804..2236119 (2316 bp)
Type: Others
Protein ID: WP_003899120.1
Location: 2236116..2236388 (273 bp)
Type: Others
Protein ID: WP_003410017.1
Location: 2236441..2236797 (357 bp)
Type: Others
Protein ID: WP_003410018.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FPK04_RS103252228824..2229423+600WP_003409989.1L-lysine exporter-
FPK04_RS103302229839..2230267+429WP_003409992.1cellulose-binding protein-
FPK04_RS103352230493..2231032+540WP_003900446.123S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37)-
FPK04_RS103402231552..2232112-561WP_003410001.1RES family NAD+ phosphorylase-
FPK04_RS103452232109..2232450-342WP_003410003.1DUF2384 domain-containing protein-
FPK04_RS103502232536..2232793+258WP_003410006.1hypothetical protein-
FPK04_RS103552232694..2233029-336WP_003410009.1dehydrogenase-
FPK04_RS103602233118..2233462-345WP_003410010.1type II toxin-antitoxin system toxin endoribonuclease MazF6Toxin
FPK04_RS103652233456..2233704-249WP_003410014.1ribbon-helix-helix protein, CopG familyAntitoxin
FPK04_RS103702233804..2236119-2316WP_003899120.1cation transporter ATPase CptG-
FPK04_RS103752236116..2236388-273WP_003410017.1DUF1490 family protein-
FPK04_RS103802236441..2236797-357WP_003410018.1Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR-
FPK04_RS103852236945..2237712+768WP_003900447.1hemerythrin domain-containing protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12230.12 Da        Isoelectric Point: 9.8887

>T130310 WP_003410010.1 NZ_CP041805:c2233462-2233118 [Mycobacterium tuberculosis]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Download         Length: 345 bp

>T130310 NZ_CP041805:c2233462-2233118 [Mycobacterium tuberculosis]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.34 Da        Isoelectric Point: 4.3757

>AT130310 WP_003410014.1 NZ_CP041805:c2233704-2233456 [Mycobacterium tuberculosis]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW

Download         Length: 249 bp

>AT130310 NZ_CP041805:c2233704-2233456 [Mycobacterium tuberculosis]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
PDB5HK3
PDB5HK0
PDB5HKC

Antitoxin

Loading, please wait
Source
ID
Structure
PDB7WJ0
PDB7WNR
AlphaFold DBA0A7U4FAW9

References