Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1936048..1936661 Replicon chromosome
Accession NZ_CP041805
Organism Mycobacterium tuberculosis strain SEA11020068P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag FPK04_RS08935 Protein ID WP_003408465.1
Coordinates 1936048..1936437 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag FPK04_RS08940 Protein ID WP_003408469.1
Coordinates 1936434..1936661 (-) Length 76 a.a.

Genomic Context

FPK04_RS08905FPK04_RS08910FPK04_RS08915FPK04_RS08920FPK04_RS08925FPK04_RS08945FPK04_RS08950FPK04_RS08935FPK04_RS08940FPK04_RS08955FPK04_RS08960
Location: 1931677..1932591 (915 bp)
Type: Others
Protein ID: WP_003898985.1
Location: 1932594..1933424 (831 bp)
Type: Others
Protein ID: WP_003408448.1
Location: 1933424..1933774 (351 bp)
Type: Others
Protein ID: WP_003898986.1
Location: 1933827..1934645 (819 bp)
Type: Others
Protein ID: WP_003408456.1
Location: 1934659..1935438 (780 bp)
Type: Others
Protein ID: WP_003408460.1
Location: 1936879..1938363 (1485 bp)
Type: Others
Protein ID: WP_003408473.1
Location: 1938360..1939607 (1248 bp)
Type: Others
Protein ID: WP_003408476.1
Location: 1936048..1936437 (390 bp)
Type: Toxin
Protein ID: WP_003408465.1
Location: 1936434..1936661 (228 bp)
Type: Antitoxin
Protein ID: WP_003408469.1
Location: 1939650..1940069 (420 bp)
Type: Others
Protein ID: WP_003408483.1
Location: 1940059..1940769 (711 bp)
Type: Others
Protein ID: WP_003408486.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FPK04_RS089051931677..1932591+915WP_003898985.13-hydroxyacyl-CoA dehydrogenase family protein-
FPK04_RS089101932594..1933424+831WP_003408448.1cyclase family protein-
FPK04_RS089151933424..1933774+351WP_003898986.1cupin domain-containing protein-
FPK04_RS089201933827..1934645+819WP_003408456.13-keto-5-aminohexanoate cleavage protein-
FPK04_RS089251934659..1935438+780WP_003408460.1IclR family transcriptional regulator-
FPK04_RS089351936048..1936437-390WP_003408465.1PIN domain-containing proteinToxin
FPK04_RS089401936434..1936661-228WP_003408469.1antitoxinAntitoxin
FPK04_RS089451936879..1938363+1485WP_003408473.1carboxylase-
FPK04_RS089501938360..1939607+1248WP_003408476.1serine hydrolase-
FPK04_RS089551939650..1940069-420WP_003408483.1hypothetical protein-
FPK04_RS089601940059..1940769-711WP_003408486.1winged helix-turn-helix transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T130303 WP_003408465.1 NZ_CP041805:c1936437-1936048 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T130303 NZ_CP041805:c1936437-1936048 [Mycobacterium tuberculosis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT130303 WP_003408469.1 NZ_CP041805:c1936661-1936434 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT130303 NZ_CP041805:c1936661-1936434 [Mycobacterium tuberculosis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7U4BUI9

Antitoxin

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Source
ID
Structure
PDB7E4J
AlphaFold DBA0A7U4FAN9

References