Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3768909..3769438 Replicon chromosome
Accession NZ_CP041803
Organism Mycobacterium tuberculosis strain SEA11278P6C4

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag FPK06_RS17450 Protein ID WP_003417760.1
Coordinates 3769181..3769438 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag FPK06_RS17445 Protein ID WP_003417757.1
Coordinates 3768909..3769184 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK06_RS17425 3765707..3767144 - 1438 Protein_3441 FAD-binding oxidoreductase -
FPK06_RS17430 3767247..3767636 + 390 WP_050069136.1 DUF732 domain-containing protein -
FPK06_RS17435 3767650..3767943 - 294 WP_003417749.1 DUF3017 domain-containing protein -
FPK06_RS17440 3767940..3768785 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
FPK06_RS17445 3768909..3769184 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
FPK06_RS17450 3769181..3769438 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
FPK06_RS17455 3769480..3770670 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
FPK06_RS17460 3770787..3771155 + 369 WP_003417765.1 FHA domain-containing protein -
FPK06_RS17465 3771152..3771703 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
FPK06_RS17470 3771710..3772291 - 582 WP_003417769.1 ATP/GTP-binding protein -
FPK06_RS17475 3772272..3772640 - 369 WP_003417772.1 DUF742 domain-containing protein -
FPK06_RS17480 3772621..3773010 - 390 WP_050069135.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T130210 WP_003417760.1 NZ_CP041803:3769181-3769438 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T130210 NZ_CP041803:3769181-3769438 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT130210 WP_003417757.1 NZ_CP041803:3768909-3769184 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT130210 NZ_CP041803:3768909-3769184 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References