Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 3105467..3106037 | Replicon | chromosome |
Accession | NZ_CP041803 | ||
Organism | Mycobacterium tuberculosis strain SEA11278P6C4 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | P71650 |
Locus tag | FPK06_RS14530 | Protein ID | WP_003414166.1 |
Coordinates | 3105467..3105823 (-) | Length | 119 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | P0CL61 |
Locus tag | FPK06_RS14535 | Protein ID | WP_003901465.1 |
Coordinates | 3105807..3106037 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FPK06_RS14510 | 3100919..3102607 | - | 1689 | WP_003414155.1 | alpha/beta hydrolase family protein | - |
FPK06_RS14515 | 3102611..3102937 | - | 327 | WP_193019635.1 | hypothetical protein | - |
FPK06_RS14520 | 3103110..3103697 | + | 588 | WP_003914429.1 | DUF3558 family protein | - |
FPK06_RS14525 | 3103716..3105365 | + | 1650 | WP_003899485.1 | CocE/NonD family hydrolase | - |
FPK06_RS14530 | 3105467..3105823 | - | 357 | WP_003414166.1 | type II toxin-antitoxin system toxin endoribonuclease MazF9 | Toxin |
FPK06_RS14535 | 3105807..3106037 | - | 231 | WP_003901465.1 | antitoxin MazE | Antitoxin |
FPK06_RS14540 | 3106080..3107123 | - | 1044 | WP_003414172.1 | DUF2293 domain-containing protein | - |
FPK06_RS14545 | 3107314..3107589 | + | 276 | WP_003911993.1 | DUF1778 domain-containing protein | - |
FPK06_RS14550 | 3107765..3108019 | - | 255 | WP_003917684.1 | hypothetical protein | - |
FPK06_RS14555 | 3108167..3108571 | + | 405 | WP_003414181.1 | hypothetical protein | - |
FPK06_RS14560 | 3108568..3108759 | + | 192 | WP_003414184.1 | hypothetical protein | - |
FPK06_RS14565 | 3108823..3110112 | + | 1290 | Protein_2874 | transposase family protein | - |
FPK06_RS14570 | 3110346..3110603 | + | 258 | WP_003899489.1 | hypothetical protein | - |
FPK06_RS14575 | 3110708..3111019 | + | 312 | WP_003414190.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 12858.73 Da Isoelectric Point: 9.1962
>T130203 WP_003414166.1 NZ_CP041803:c3105823-3105467 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
Download Length: 357 bp
>T130203 NZ_CP041803:c3105823-3105467 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG
Antitoxin
Download Length: 77 a.a. Molecular weight: 8231.01 Da Isoelectric Point: 4.1809
>AT130203 WP_003901465.1 NZ_CP041803:c3106037-3105807 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
Download Length: 231 bp
>AT130203 NZ_CP041803:c3106037-3105807 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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