Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2936144..2936858 Replicon chromosome
Accession NZ_CP041803
Organism Mycobacterium tuberculosis strain SEA11278P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag FPK06_RS13560 Protein ID WP_003413460.1
Coordinates 2936418..2936858 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag FPK06_RS13555 Protein ID WP_003413456.1
Coordinates 2936144..2936431 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK06_RS13520 2931566..2931811 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
FPK06_RS13525 2931808..2932212 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
FPK06_RS13530 2932429..2933049 + 621 WP_003413441.1 DUF4178 domain-containing protein -
FPK06_RS13535 2933060..2933554 + 495 WP_003413444.1 DUF2617 family protein -
FPK06_RS13540 2933551..2933982 + 432 WP_003413445.1 DUF4247 domain-containing protein -
FPK06_RS13545 2934007..2934465 + 459 WP_003413451.1 DUF350 domain-containing protein -
FPK06_RS13550 2934462..2936033 + 1572 WP_050069397.1 polyamine aminopropyltransferase -
FPK06_RS13555 2936144..2936431 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
FPK06_RS13560 2936418..2936858 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
FPK06_RS13565 2936879..2937634 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
FPK06_RS13570 2937767..2938363 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
FPK06_RS13575 2938371..2939216 - 846 WP_050069396.1 acyl-CoA thioesterase II -
FPK06_RS13580 2939245..2940144 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
FPK06_RS13585 2940272..2940946 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T130200 WP_003413460.1 NZ_CP041803:2936418-2936858 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T130200 NZ_CP041803:2936418-2936858 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT130200 WP_003413456.1 NZ_CP041803:2936144-2936431 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT130200 NZ_CP041803:2936144-2936431 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References