Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
Location | 2874255..2874964 | Replicon | chromosome |
Accession | NZ_CP041803 | ||
Organism | Mycobacterium tuberculosis strain SEA11278P6C4 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TQ26 |
Locus tag | FPK06_RS13275 | Protein ID | WP_003413164.1 |
Coordinates | 2874255..2874668 (+) | Length | 138 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P95006 |
Locus tag | FPK06_RS13280 | Protein ID | WP_003413167.1 |
Coordinates | 2874707..2874964 (+) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FPK06_RS13245 | 2869965..2870279 | + | 315 | WP_009937839.1 | hypothetical protein | - |
FPK06_RS13250 | 2870575..2871786 | + | 1212 | WP_003900845.1 | alpha/beta hydrolase family protein | - |
FPK06_RS13255 | 2871913..2872572 | + | 660 | WP_050069193.1 | LppA family lipoprotein | - |
FPK06_RS13260 | 2872569..2873228 | + | 660 | WP_003900847.1 | hypothetical protein | - |
FPK06_RS13265 | 2873225..2873860 | + | 636 | WP_031685723.1 | hypothetical protein | - |
FPK06_RS13270 | 2873884..2874162 | + | 279 | WP_003901422.1 | type II toxin-antitoxin system VapB family antitoxin | - |
FPK06_RS13275 | 2874255..2874668 | + | 414 | WP_003413164.1 | PIN domain nuclease | Toxin |
FPK06_RS13280 | 2874707..2874964 | + | 258 | WP_003413167.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
FPK06_RS13285 | 2874961..2875338 | + | 378 | WP_003413174.1 | type II toxin-antitoxin system VapC family toxin | - |
FPK06_RS13290 | 2875354..2875728 | - | 375 | WP_003413177.1 | hypothetical protein | - |
FPK06_RS13295 | 2875828..2876223 | - | 396 | WP_003413180.1 | type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 | - |
FPK06_RS13300 | 2876220..2876465 | - | 246 | WP_003413183.1 | type II toxin-antitoxin system antitoxin VapB20 | - |
FPK06_RS13305 | 2876876..2877295 | - | 420 | WP_003413190.1 | A24 family peptidase | - |
FPK06_RS13310 | 2877307..2878116 | - | 810 | WP_003413193.1 | shikimate dehydrogenase | - |
FPK06_RS13315 | 2878113..2879366 | - | 1254 | WP_003413196.1 | endolytic transglycosylase MltG | - |
FPK06_RS13320 | 2879359..2879871 | - | 513 | WP_003413197.1 | Holliday junction resolvase RuvX | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 138 a.a. Molecular weight: 15045.00 Da Isoelectric Point: 5.4673
>T130197 WP_003413164.1 NZ_CP041803:2874255-2874668 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL
Download Length: 414 bp
>T130197 NZ_CP041803:2874255-2874668 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9453.63 Da Isoelectric Point: 10.6555
>AT130197 WP_003413167.1 NZ_CP041803:2874707-2874964 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
Download Length: 258 bp
>AT130197 NZ_CP041803:2874707-2874964 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TQ26 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829C9W5 |