Detailed information of TA system TA130176

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1384842..1385530
• Replicon: chromosome
• Accession: NZ_CP041803
• Organism: Mycobacterium tuberculosis strain SEA11278P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: FPK06_RS06495
• Protein ID: WP_003406304.1
• Coordinates: 1385099..1385530 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FPK06_RS06490
• Protein ID: WP_050069455.1
• Coordinates: 1384842..1385102 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPK06_RS06470	1380419..1381243	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
FPK06_RS06475	1381248..1382429	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
FPK06_RS06480	1382506..1383606	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
FPK06_RS06485	1383777..1384766	+	990	WP_003406301.1	malate dehydrogenase	-
FPK06_RS06490	1384842..1385102	+	261	WP_050069455.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
FPK06_RS06495	1385099..1385530	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPK06_RS06500	1385553..1387238	-	1686	WP_031719099.1	PE family protein	-
FPK06_RS06505	1387418..1388278	+	861	WP_003900301.1	hypothetical protein	-
FPK06_RS06510	1388359..1389189	-	831	WP_050069448.1	SDR family NAD(P)-dependent oxidoreductase	-
FPK06_RS06515	1389246..1389539	-	294	WP_050069449.1	type II toxin-antitoxin system mRNA interferase RelE	-
FPK06_RS06520	1389536..1389805	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T130176 WP_003406304.1 NZ_CP041803:1385099-1385530 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T130176 NZ_CP041803:1385099-1385530 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9908.23 Da
• Isoelectric Point: 6.4693

>AT130176 WP_050069455.1 NZ_CP041803:1384842-1385102 [Mycobacterium tuberculosis]
MRTTCTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT130176 NZ_CP041803:1384842-1385102 [Mycobacterium tuberculosis]
ATGCGCACCACCTGCACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7