Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 758554..759346 Replicon chromosome
Accession NZ_CP041803
Organism Mycobacterium tuberculosis strain SEA11278P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag FPK06_RS03480 Protein ID WP_003403386.1
Coordinates 758909..759346 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag FPK06_RS03475 Protein ID WP_003403381.1
Coordinates 758554..758799 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK06_RS03445 753573..755079 + 1507 Protein_680 carotenoid cleavage oxygenase -
FPK06_RS03450 755160..756170 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
FPK06_RS03455 756558..756941 - 384 WP_003403365.1 ribonuclease VapC6 -
FPK06_RS03460 757036..757191 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
FPK06_RS03465 757267..757983 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
FPK06_RS03470 758259..758567 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
FPK06_RS03475 758554..758799 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
FPK06_RS03480 758909..759346 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
FPK06_RS03485 759343..759597 - 255 WP_003911263.1 antitoxin VapB7 -
FPK06_RS03490 759711..762074 + 2364 WP_003403397.1 arylsulfatase AtsD -
FPK06_RS03495 762137..762463 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPK06_RS03500 762375..762713 + 339 WP_003403405.1 PIN domain-containing protein -
FPK06_RS03505 762710..762883 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T130168 WP_003403386.1 NZ_CP041803:c759346-758909 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T130168 NZ_CP041803:c759346-758909 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT130168 WP_003403381.1 NZ_CP041803:c758799-758554 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT130168 NZ_CP041803:c758799-758554 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References