Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 713813..714438 Replicon chromosome
Accession NZ_CP041803
Organism Mycobacterium tuberculosis strain SEA11278P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag FPK06_RS03235 Protein ID WP_003403218.1
Coordinates 714037..714438 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag FPK06_RS03230 Protein ID WP_003403213.1
Coordinates 713813..714040 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK06_RS03205 708992..709213 - 222 WP_003898525.1 DUF4926 domain-containing protein -
FPK06_RS03210 709355..709960 + 606 WP_003898526.1 hypothetical protein -
FPK06_RS03215 709979..712546 - 2568 WP_050069302.1 SEC-C domain-containing protein -
FPK06_RS03220 712630..713379 + 750 WP_003898528.1 hypothetical protein -
FPK06_RS03225 713376..713618 + 243 WP_003403210.1 hypothetical protein -
FPK06_RS03230 713813..714040 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
FPK06_RS03235 714037..714438 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
FPK06_RS03240 714567..715262 + 696 WP_078800621.1 galactose-1-phosphate uridylyltransferase -
FPK06_RS03245 715259..715750 + 492 WP_003905354.1 galactose-1-phosphate uridylyltransferase -
FPK06_RS03250 715747..716838 + 1092 WP_003900977.1 galactokinase -
FPK06_RS03255 717233..718390 + 1158 WP_003903091.1 hypothetical protein -
FPK06_RS03260 718401..719348 + 948 WP_050069287.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T130163 WP_003403218.1 NZ_CP041803:714037-714438 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T130163 NZ_CP041803:714037-714438 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT130163 WP_003403213.1 NZ_CP041803:713813-714040 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT130163 NZ_CP041803:713813-714040 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References