130143

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3106525..3107095 Replicon chromosome
Accession NZ_CP041802
Organism Mycobacterium tuberculosis strain SEA12126P6C4

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag FPK07_RS14565 Protein ID WP_003414166.1
Coordinates 3106525..3106881 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag FPK07_RS14570 Protein ID WP_003901465.1
Coordinates 3106865..3107095 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK07_RS14545 3101977..3103665 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
FPK07_RS14550 3103669..3103995 - 327 WP_003414157.1 hypothetical protein -
FPK07_RS14555 3104168..3104755 + 588 WP_003914429.1 DUF3558 family protein -
FPK07_RS14560 3104774..3106423 + 1650 WP_003899485.1 CocE/NonD family hydrolase -
FPK07_RS14565 3106525..3106881 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
FPK07_RS14570 3106865..3107095 - 231 WP_003901465.1 antitoxin MazE Antitoxin
FPK07_RS14575 3107138..3108181 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
FPK07_RS14580 3108372..3108647 + 276 WP_003911993.1 DUF1778 domain-containing protein -
FPK07_RS14585 3108823..3109077 - 255 WP_003917684.1 hypothetical protein -
FPK07_RS14590 3109225..3109629 + 405 WP_003414181.1 hypothetical protein -
FPK07_RS14595 3109626..3109817 + 192 WP_003414184.1 hypothetical protein -
FPK07_RS14600 3109881..3111170 + 1290 Protein_2881 transposase family protein -
FPK07_RS14605 3111404..3111661 + 258 WP_003899489.1 hypothetical protein -
FPK07_RS14610 3111766..3112077 + 312 WP_193020312.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T130143 WP_003414166.1 NZ_CP041802:c3106881-3106525 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

>T130143 NZ_CP041802:c3106881-3106525 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT130143 WP_003901465.1 NZ_CP041802:c3107095-3106865 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp

>AT130143 NZ_CP041802:c3107095-3106865 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FBW3

References