130039

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 645768..646444 Replicon chromosome
Accession NZ_CP041801
Organism Mycobacterium tuberculosis strain SEA12202P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TPQ9
Locus tag FPK08_RS02885 Protein ID WP_003898500.1
Coordinates 645768..646181 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TPR0
Locus tag FPK08_RS02890 Protein ID WP_003402915.1
Coordinates 646178..646444 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK08_RS02855 641113..641415 - 303 WP_003402896.1 DUF3349 domain-containing protein -
FPK08_RS02860 641475..641753 - 279 WP_003402901.1 hypothetical protein -
FPK08_RS02865 641750..643003 - 1254 WP_003402904.1 inorganic phosphate transporter family protein -
FPK08_RS02870 643123..643509 - 387 WP_003402907.1 VOC family protein -
FPK08_RS02875 643572..644456 - 885 WP_003903053.1 SDR family oxidoreductase -
FPK08_RS02880 644552..645454 - 903 WP_031654206.1 1,4-dihydroxy-2-naphthoyl-CoA synthase -
FPK08_RS02885 645768..646181 - 414 WP_003898500.1 PIN domain-containing protein Toxin
FPK08_RS02890 646178..646444 - 267 WP_003402915.1 antitoxin VapB3 Antitoxin
FPK08_RS02895 646636..648351 - 1716 WP_078429506.1 fatty-acid--CoA ligase FadD8 -
FPK08_RS02900 648429..650033 + 1605 WP_003903056.1 amidohydrolase -
FPK08_RS02905 650023..651009 + 987 WP_031714900.1 o-succinylbenzoate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(13-129)

Antitoxin

Post-segregation antitoxin CcdA

(19-61)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14667.78 Da        Isoelectric Point: 7.3603

>T130039 WP_003898500.1 NZ_CP041801:c646181-645768 [Mycobacterium tuberculosis]
VRASPTSPPEQVVVDASAMVDLLARTSDRCSAVRARLARTAMHAPAHFDAEVLSALGRMQRAGALTVAYVDAALEELRQV
PVTRHGLSSLLAGAWSRRDTLRLTDALYVELAETAGLVLLTTDERLARAWPSAHAIG

Download         Length: 414 bp

>T130039 NZ_CP041801:c646181-645768 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9543.79 Da        Isoelectric Point: 4.5994

>AT130039 WP_003402915.1 NZ_CP041801:c646444-646178 [Mycobacterium tuberculosis]
MLSRRTKTIVVCTLVCMARLNVYVPDELAERARARGLNVSALTQAAISAELENSATDAWLEGLEPRSTGARHDDVLGAID
AARDEFEA

Download         Length: 267 bp

>AT130039 NZ_CP041801:c646444-646178 [Mycobacterium tuberculosis]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPQ9

Antitoxin

Source ID Structure
AlphaFold DB G0TPR0

References