Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3729062..3729736 Replicon chromosome
Accession NZ_CP041800
Organism Mycobacterium tuberculosis strain SEA12334P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag FPK09_RS17430 Protein ID WP_003417282.1
Coordinates 3729062..3729490 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag FPK09_RS17435 Protein ID WP_003417286.1
Coordinates 3729494..3729736 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK09_RS17405 3724884..3725285 - 402 WP_003417264.1 cytidine deaminase -
FPK09_RS17410 3725426..3725860 + 435 WP_072460198.1 succinate dehydrogenase, cytochrome b556 subunit -
FPK09_RS17415 3725857..3726291 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
FPK09_RS17420 3726420..3728192 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
FPK09_RS17425 3728192..3728983 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
FPK09_RS17430 3729062..3729490 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
FPK09_RS17435 3729494..3729736 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
FPK09_RS17440 3729858..3730472 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
FPK09_RS17445 3730469..3731134 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
FPK09_RS17450 3731135..3731668 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
FPK09_RS17455 3731665..3731865 - 201 WP_151851546.1 4a-hydroxytetrahydrobiopterin dehydratase -
FPK09_RS17460 3731864..3733125 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T130030 WP_003417282.1 NZ_CP041800:c3729490-3729062 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T130030 NZ_CP041800:c3729490-3729062 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT130030 WP_003417286.1 NZ_CP041800:c3729736-3729494 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT130030 NZ_CP041800:c3729736-3729494 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References