Detailed information of TA system TA130030

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3729062..3729736
• Replicon: chromosome
• Accession: NZ_CP041800
• Organism: Mycobacterium tuberculosis strain SEA12334P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P9WF52
• Locus tag: FPK09_RS17430
• Protein ID: WP_003417282.1
• Coordinates: 3729062..3729490 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TI59
• Locus tag: FPK09_RS17435
• Protein ID: WP_003417286.1
• Coordinates: 3729494..3729736 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPK09_RS17405	3724884..3725285	-	402	WP_003417264.1	cytidine deaminase	-
FPK09_RS17410	3725426..3725860	+	435	WP_072460198.1	succinate dehydrogenase, cytochrome b556 subunit	-
FPK09_RS17415	3725857..3726291	+	435	WP_003417269.1	succinate dehydrogenase hydrophobic membrane anchor subunit	-
FPK09_RS17420	3726420..3728192	+	1773	WP_003417273.1	succinate dehydrogenase flavoprotein subunit	-
FPK09_RS17425	3728192..3728983	+	792	WP_003417279.1	succinate dehydrogenase iron-sulfur subunit	-
FPK09_RS17430	3729062..3729490	-	429	WP_003417282.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPK09_RS17435	3729494..3729736	-	243	WP_003417286.1	ribbon-helix-helix domain-containing protein	Antitoxin
FPK09_RS17440	3729858..3730472	-	615	WP_003417288.1	class I SAM-dependent methyltransferase	-
FPK09_RS17445	3730469..3731134	-	666	WP_003417290.1	molybdopterin converting factor subunit 1	-
FPK09_RS17450	3731135..3731668	-	534	WP_003417293.1	cyclic pyranopterin monophosphate synthase MoaC	-
FPK09_RS17455	3731665..3731865	-	201	WP_151851546.1	4a-hydroxytetrahydrobiopterin dehydratase	-
FPK09_RS17460	3731864..3733125	+	1262	WP_087902221.1	IS3-like element IS987 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-141)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15834.16 Da
• Isoelectric Point: 8.5471

>T130030 WP_003417282.1 NZ_CP041800:c3729490-3729062 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Nucleotide

• Length: 429 bp

>T130030 NZ_CP041800:c3729490-3729062 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8849.86 Da
• Isoelectric Point: 5.1007

>AT130030 WP_003417286.1 NZ_CP041800:c3729736-3729494 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Nucleotide

• Length: 243 bp

>AT130030 NZ_CP041800:c3729736-3729494 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Structures

Toxin

• AlphaFold DB: A0A7U4FBL0

Antitoxin

• AlphaFold DB: G0TI59