Detailed information of TA system TA130017

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2875983..2876623
• Replicon: chromosome
• Accession: NZ_CP041800
• Organism: Mycobacterium tuberculosis strain SEA12334P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ08
• Locus tag: FPK09_RS13310
• Protein ID: WP_003412970.1
• Coordinates: 2875983..2876402 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ09
• Locus tag: FPK09_RS13315
• Protein ID: WP_003412975.1
• Coordinates: 2876399..2876623 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPK09_RS13280	2871568..2872290	-	723	WP_003412957.1	DUF1906 domain-containing protein	-
FPK09_RS13285	2872807..2873034	+	228	WP_003412960.1	type II toxin-antitoxin system VapB family antitoxin	-
FPK09_RS13290	2873031..2873432	+	402	WP_003412963.1	PIN domain-containing protein	-
FPK09_RS13295	2873467..2874387	-	921	WP_003412965.1	restriction endonuclease	-
FPK09_RS13300	2874728..2874973	-	246	WP_071854223.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
FPK09_RS13305	2875032..2875982	+	951	WP_003911916.1	Lsr2 family protein	-
FPK09_RS13310	2875983..2876402	-	420	WP_003412970.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPK09_RS13315	2876399..2876623	-	225	WP_003412975.1	antitoxin VapB39	Antitoxin
FPK09_RS13320	2876654..2879447	-	2794	Protein_2629	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
FPK09_RS13325	2879519..2879920	-	402	WP_003412981.1	hypothetical protein	-
FPK09_RS13330	2879920..2880390	-	471	WP_003412985.1	transcription antitermination factor NusB	-
FPK09_RS13335	2880393..2880956	-	564	WP_031721070.1	elongation factor P	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14732.70 Da
• Isoelectric Point: 6.7519

>T130017 WP_003412970.1 NZ_CP041800:c2876402-2875983 [Mycobacterium tuberculosis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Nucleotide

• Length: 420 bp

>T130017 NZ_CP041800:c2876402-2875983 [Mycobacterium tuberculosis]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 7993.94 Da
• Isoelectric Point: 4.0057

>AT130017 WP_003412975.1 NZ_CP041800:c2876623-2876399 [Mycobacterium tuberculosis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Nucleotide

• Length: 225 bp

>AT130017 NZ_CP041800:c2876623-2876399 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Structures

Toxin

• AlphaFold DB: G0TQ08

Antitoxin

• AlphaFold DB: G0TQ09