Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1955025..1955638 Replicon chromosome
Accession NZ_CP041800
Organism Mycobacterium tuberculosis strain SEA12334P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag FPK09_RS09000 Protein ID WP_003408465.1
Coordinates 1955025..1955414 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag FPK09_RS09005 Protein ID WP_003408469.1
Coordinates 1955411..1955638 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK09_RS08970 1950654..1951568 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
FPK09_RS08975 1951571..1952401 + 831 WP_003408448.1 cyclase family protein -
FPK09_RS08980 1952401..1952751 + 351 WP_003898986.1 cupin domain-containing protein -
FPK09_RS08985 1952804..1953622 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
FPK09_RS08990 1953636..1954415 + 780 WP_003408460.1 IclR family transcriptional regulator -
FPK09_RS09000 1955025..1955414 - 390 WP_003408465.1 PIN domain-containing protein Toxin
FPK09_RS09005 1955411..1955638 - 228 WP_003408469.1 antitoxin Antitoxin
FPK09_RS09010 1955856..1957340 + 1485 WP_003408473.1 carboxylase -
FPK09_RS09015 1957337..1958371 + 1035 Protein_1778 serine hydrolase -
FPK09_RS09020 1958423..1959684 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
FPK09_RS09025 1959727..1959942 + 216 Protein_1780 hydrolase -
FPK09_RS09030 1959985..1960404 - 420 WP_003408483.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T130003 WP_003408465.1 NZ_CP041800:c1955414-1955025 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T130003 NZ_CP041800:c1955414-1955025 [Mycobacterium tuberculosis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT130003 WP_003408469.1 NZ_CP041800:c1955638-1955411 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT130003 NZ_CP041800:c1955638-1955411 [Mycobacterium tuberculosis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References