Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1242675..1243243 Replicon chromosome
Accession NZ_CP041800
Organism Mycobacterium tuberculosis strain SEA12334P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TH08
Locus tag FPK09_RS05850 Protein ID WP_003405865.1
Coordinates 1242869..1243243 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TH07
Locus tag FPK09_RS05845 Protein ID WP_003405863.1
Coordinates 1242675..1242872 (+) Length 66 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK09_RS05825 1238716..1239354 - 639 WP_003898730.1 lipid droplet-associated protein -
FPK09_RS05830 1239444..1240451 + 1008 WP_031674288.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
FPK09_RS05835 1240468..1241451 - 984 WP_003903326.1 hypothetical protein -
FPK09_RS05840 1241514..1242587 + 1074 WP_003898732.1 redox-regulated ATPase YchF -
FPK09_RS05845 1242675..1242872 + 198 WP_003405863.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FPK09_RS05850 1242869..1243243 + 375 WP_003405865.1 type II toxin-antitoxin system VapC family toxin Toxin
FPK09_RS05855 1243446..1244144 + 699 WP_003898733.1 hypothetical protein -
FPK09_RS05860 1244262..1244447 + 186 WP_003901093.1 hypothetical protein -
FPK09_RS05865 1244374..1244649 - 276 WP_003405867.1 hypothetical protein -
FPK09_RS05870 1244892..1245215 + 324 WP_003405871.1 antibiotic biosynthesis monooxygenase -
FPK09_RS05875 1245230..1245940 - 711 WP_003911399.1 hypothetical protein -
FPK09_RS05880 1245962..1246171 + 210 WP_003911400.1 hypothetical protein -
FPK09_RS05885 1246123..1246830 - 708 Protein_1159 adenylate/guanylate cyclase domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-111)

Antitoxin

(1-42)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13444.56 Da        Isoelectric Point: 5.1881

>T129996 WP_003405865.1 NZ_CP041800:1242869-1243243 [Mycobacterium tuberculosis]
VILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGR
GLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS

Download         Length: 375 bp

>T129996 NZ_CP041800:1242869-1243243 [Mycobacterium tuberculosis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTTACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6973.03 Da        Isoelectric Point: 11.7327

>AT129996 WP_003405863.1 NZ_CP041800:1242675-1242872 [Mycobacterium tuberculosis]
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR

Download         Length: 198 bp

>AT129996 NZ_CP041800:1242675-1242872 [Mycobacterium tuberculosis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TH08


Antitoxin

Source ID Structure
AlphaFold DB G0TH07

References