Detailed information of TA system TA129983

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 707554..708197
• Replicon: chromosome
• Accession: NZ_CP041800
• Organism: Mycobacterium tuberculosis strain SEA12334P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P67239
• Locus tag: FPK09_RS03175
• Protein ID: WP_003403187.1
• Coordinates: 707796..708197 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ91
• Locus tag: FPK09_RS03170
• Protein ID: WP_003403184.1
• Coordinates: 707554..707799 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPK09_RS03135	702834..703364	-	531	WP_003917320.1	two component system sensor kinase HK2	-
FPK09_RS03140	703348..704109	-	762	WP_003403148.1	two-component system response regulator TcrA	-
FPK09_RS03145	704166..704477	+	312	WP_003403164.1	hypothetical protein	-
FPK09_RS03150	704549..705499	+	951	WP_003907436.1	DUF1259 domain-containing protein	-
FPK09_RS03155	705740..706324	+	585	WP_003403171.1	IS607-like element IS1536 family transposase	-
FPK09_RS03160	706326..707036	+	711	Protein_626	transposase	-
FPK09_RS03165	707039..707509	+	471	WP_003898523.1	hypothetical protein	-
FPK09_RS03170	707554..707799	+	246	WP_003403184.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FPK09_RS03175	707796..708197	+	402	WP_003403187.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPK09_RS03180	708585..708752	-	168	WP_077385191.1	DUF3800 domain-containing protein	-
FPK09_RS03185	708785..708982	-	198	WP_003403191.1	hypothetical protein	-
FPK09_RS03190	709013..709186	-	174	WP_158656766.1	hypothetical protein	-
FPK09_RS03195	709305..710219	-	915	WP_003908555.1	hypothetical protein	-
FPK09_RS03200	710271..710492	-	222	WP_003898525.1	DUF4926 domain-containing protein	-
FPK09_RS03205	710634..711239	+	606	WP_003898526.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-80)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14501.21 Da
• Isoelectric Point: 4.4463

>T129983 WP_003403187.1 NZ_CP041800:707796-708197 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Nucleotide

• Length: 402 bp

>T129983 NZ_CP041800:707796-708197 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8813.12 Da
• Isoelectric Point: 10.3486

>AT129983 WP_003403184.1 NZ_CP041800:707554-707799 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Nucleotide

• Length: 246 bp

>AT129983 NZ_CP041800:707554-707799 [Mycobacterium tuberculosis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Structures

Toxin

• AlphaFold DB: A0A7U4BSD6

Antitoxin

• AlphaFold DB: G0TQ91