Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3697275..3697924 Replicon chromosome
Accession NZ_CP041799
Organism Mycobacterium tuberculosis strain SEA13020298P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag FPK10_RS17320 Protein ID WP_003403236.1
Coordinates 3697275..3697670 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag FPK10_RS17325 Protein ID WP_003403235.1
Coordinates 3697670..3697924 (-) Length 85 a.a.

Genomic Context

FPK10_RS17295FPK10_RS17300FPK10_RS17315FPK10_RS17305FPK10_RS17310FPK10_RS17320FPK10_RS17325FPK10_RS17330FPK10_RS17335FPK10_RS17340FPK10_RS17345FPK10_RS17350
Location: 3692602..3694329 (1728 bp)
Type: Others
Protein ID: WP_003901883.1
Location: 3694422..3695573 (1152 bp)
Type: Others
Protein ID: WP_003403248.1
Location: 3696441..3697181 (741 bp)
Type: Others
Protein ID: WP_003403239.1
Location: 3695645..3696052 (408 bp)
Type: Others
Protein ID: WP_003403246.1
Location: 3696049..3696309 (261 bp)
Type: Others
Protein ID: WP_003403244.1
Location: 3697275..3697670 (396 bp)
Type: Toxin
Protein ID: WP_003403236.1
Location: 3697670..3697924 (255 bp)
Type: Antitoxin
Protein ID: WP_003403235.1
Location: 3698017..3698964 (948 bp)
Type: Others
Protein ID: WP_003403232.1
Location: 3699068..3700132 (1065 bp)
Type: Others
Protein ID: WP_003898532.1
Location: 3700527..3701618 (1092 bp)
Type: Others
Protein ID: WP_003900977.1
Location: 3701615..3702106 (492 bp)
Type: Others
Protein ID: WP_003905354.1
Location: 3702103..3702798 (696 bp)
Type: Others
Protein ID: WP_003900189.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FPK10_RS172953692602..3694329+1728WP_003901883.1exodeoxyribonuclease V subunit alpha-
FPK10_RS173003694422..3695573+1152WP_003403248.1FIST C-terminal domain-containing protein-
FPK10_RS173053695645..3696052-408WP_003403246.1type II toxin-antitoxin system VapC family toxin-
FPK10_RS173103696049..3696309-261WP_003403244.1type II toxin-antitoxin system Phd/YefM family antitoxin-
FPK10_RS173153696441..3697181+741WP_003403239.1TVP38/TMEM64 family protein-
FPK10_RS173203697275..3697670-396WP_003403236.1type II toxin-antitoxin system toxin ribonuclease C30Toxin
FPK10_RS173253697670..3697924-255WP_003403235.1type II toxin-antitoxin system antitoxin VapB30Antitoxin
FPK10_RS173303698017..3698964-948WP_003403232.1DUF732 domain-containing protein-
FPK10_RS173353699068..3700132-1065WP_003898532.1hypothetical protein-
FPK10_RS173403700527..3701618-1092WP_003900977.1galactokinase-
FPK10_RS173453701615..3702106-492WP_003905354.1galactose-1-phosphate uridylyltransferase-
FPK10_RS173503702103..3702798-696WP_003900189.1galactose-1-phosphate uridylyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T129969 WP_003403236.1 NZ_CP041799:c3697670-3697275 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T129969 NZ_CP041799:c3697670-3697275 [Mycobacterium tuberculosis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT129969 WP_003403235.1 NZ_CP041799:c3697924-3697670 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT129969 NZ_CP041799:c3697924-3697670 [Mycobacterium tuberculosis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB4XGR
PDB4XGQ

Antitoxin

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Source
ID
Structure
PDB4XGR
PDB4XGQ
AlphaFold DBA0A7U4BSC2

References