129954

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2884880..2885450 Replicon chromosome
Accession NZ_CP041799
Organism Mycobacterium tuberculosis strain SEA13020298P6C4

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag FPK10_RS13465 Protein ID WP_003414166.1
Coordinates 2884880..2885236 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag FPK10_RS13470 Protein ID WP_003901465.1
Coordinates 2885220..2885450 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK10_RS13445 2880333..2882021 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
FPK10_RS13450 2882025..2882351 - 327 WP_003414157.1 hypothetical protein -
FPK10_RS13455 2882524..2883110 + 587 Protein_2661 DUF3558 family protein -
FPK10_RS13460 2883129..2884778 + 1650 Protein_2662 CocE/NonD family hydrolase -
FPK10_RS13465 2884880..2885236 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
FPK10_RS13470 2885220..2885450 - 231 WP_003901465.1 antitoxin MazE Antitoxin
FPK10_RS13475 2885493..2886536 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
FPK10_RS13480 2886727..2887002 + 276 WP_003911993.1 DUF1778 domain-containing protein -
FPK10_RS13485 2887178..2887432 - 255 WP_003917684.1 hypothetical protein -
FPK10_RS13490 2887580..2887984 + 405 WP_003414181.1 hypothetical protein -
FPK10_RS13495 2887981..2888172 + 192 WP_003414184.1 hypothetical protein -
FPK10_RS13500 2888236..2889525 + 1290 Protein_2670 transposase family protein -
FPK10_RS13505 2889759..2890016 + 258 WP_003899489.1 hypothetical protein -
FPK10_RS13510 2890121..2890432 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T129954 WP_003414166.1 NZ_CP041799:c2885236-2884880 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

>T129954 NZ_CP041799:c2885236-2884880 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT129954 WP_003901465.1 NZ_CP041799:c2885450-2885220 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp

>AT129954 NZ_CP041799:c2885450-2885220 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FBW3

References