129947

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2642619..2643328 Replicon chromosome
Accession NZ_CP041799
Organism Mycobacterium tuberculosis strain SEA13020298P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag FPK10_RS12135 Protein ID WP_003413164.1
Coordinates 2642619..2643032 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag FPK10_RS12140 Protein ID WP_003413167.1
Coordinates 2643071..2643328 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK10_RS12105 2637673..2638878 - 1206 WP_003413027.1 chorismate synthase -
FPK10_RS12110 2638986..2639300 + 315 WP_009937839.1 hypothetical protein -
FPK10_RS12115 2639596..2640807 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
FPK10_RS12120 2640934..2641593 + 660 WP_003902296.1 hypothetical protein -
FPK10_RS12125 2641590..2642252 + 663 WP_003905878.1 hypothetical protein -
FPK10_RS12130 2642249..2642526 + 278 Protein_2400 type II toxin-antitoxin system VapB family antitoxin -
FPK10_RS12135 2642619..2643032 + 414 WP_003413164.1 PIN domain nuclease Toxin
FPK10_RS12140 2643071..2643328 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
FPK10_RS12145 2643325..2643702 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
FPK10_RS12150 2643718..2644092 - 375 WP_003413177.1 hypothetical protein -
FPK10_RS12155 2644192..2644587 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
FPK10_RS12160 2644584..2644829 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
FPK10_RS12165 2645240..2645659 - 420 WP_003413190.1 A24 family peptidase -
FPK10_RS12170 2645671..2646480 - 810 WP_003413193.1 shikimate dehydrogenase -
FPK10_RS12175 2646477..2647730 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
FPK10_RS12180 2647723..2648235 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T129947 WP_003413164.1 NZ_CP041799:2642619-2643032 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T129947 NZ_CP041799:2642619-2643032 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT129947 WP_003413167.1 NZ_CP041799:2643071-2643328 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT129947 NZ_CP041799:2643071-2643328 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References