Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 1970773..1971317 | Replicon | chromosome |
| Accession | NZ_CP041799 | ||
| Organism | Mycobacterium tuberculosis strain SEA13020298P6C4 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | FPK10_RS08970 | Protein ID | WP_003409896.1 |
| Coordinates | 1970773..1971069 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | FPK10_RS08975 | Protein ID | WP_003409899.1 |
| Coordinates | 1971066..1971317 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FPK10_RS08915 | 1965806..1966156 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| FPK10_RS08920 | 1966167..1967069 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| FPK10_RS08925 | 1967090..1967281 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| FPK10_RS08930 | 1967282..1967578 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| FPK10_RS08935 | 1967818..1968033 | + | 216 | WP_003409878.1 | antitoxin | - |
| FPK10_RS08940 | 1968030..1968341 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| FPK10_RS08945 | 1968315..1968836 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| FPK10_RS08950 | 1968811..1969188 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| FPK10_RS08955 | 1969230..1969679 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| FPK10_RS08960 | 1969676..1970221 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| FPK10_RS08965 | 1970110..1970724 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| FPK10_RS08970 | 1970773..1971069 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FPK10_RS08975 | 1971066..1971317 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| FPK10_RS08980 | 1971304..1971798 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| FPK10_RS08985 | 1971958..1972365 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| FPK10_RS08990 | 1972369..1972641 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FPK10_RS08995 | 1972674..1973894 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| FPK10_RS09000 | 1974793..1975590 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T129937 WP_003409896.1 NZ_CP041799:c1971069-1970773 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T129937 NZ_CP041799:c1971069-1970773 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT129937 WP_003409899.1 NZ_CP041799:c1971317-1971066 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT129937 NZ_CP041799:c1971317-1971066 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |