Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1319069..1320119 Replicon chromosome
Accession NZ_CP041799
Organism Mycobacterium tuberculosis strain SEA13020298P6C4

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag FPK10_RS06035 Protein ID WP_003407164.1
Coordinates 1319069..1319890 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag FPK10_RS06040 Protein ID WP_003407167.1
Coordinates 1319883..1320119 (+) Length 79 a.a.

Genomic Context

FPK10_RS06035FPK10_RS06040FPK10_RS06050FPK10_RS06055FPK10_RS06015FPK10_RS06020FPK10_RS06025FPK10_RS06030FPK10_RS06045
Location: 1319069..1319890 (822 bp)
Type: Toxin
Protein ID: WP_003407164.1
Location: 1319883..1320119 (237 bp)
Type: Antitoxin
Protein ID: WP_003407167.1
Location: 1321699..1322484 (786 bp)
Type: Others
Protein ID: WP_003902048.1
Location: 1322680..1323294 (615 bp)
Type: Others
Protein ID: Protein_1197
Location: 1314627..1315289 (663 bp)
Type: Others
Protein ID: WP_003407152.1
Location: 1315286..1316071 (786 bp)
Type: Others
Protein ID: WP_003407157.1
Location: 1316362..1318323 (1962 bp)
Type: Others
Protein ID: WP_003407159.1
Location: 1318462..1318848 (387 bp)
Type: Others
Protein ID: WP_003898845.1
Location: 1320191..1321396 (1206 bp)
Type: Others
Protein ID: WP_003918234.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FPK10_RS060151314627..1315289-663WP_003407152.1membrane protein-
FPK10_RS060201315286..1316071-786WP_003407157.1membrane protein-
FPK10_RS060251316362..1318323-1962WP_003407159.1sigma-F factor regulator-
FPK10_RS060301318462..1318848-387WP_003898845.1anti-sigma-F factor antagonist RsfA-
FPK10_RS060351319069..1319890+822WP_003407164.1GTP pyrophosphokinase family proteinToxin
FPK10_RS060401319883..1320119+237WP_003407167.1hypothetical proteinAntitoxin
FPK10_RS060451320191..1321396-1206WP_003918234.1serine hydrolase-
FPK10_RS060501321699..1322484+786WP_003902048.1lipoprotein LprF-
FPK10_RS060551322680..1323294+615Protein_1197cytochrome b5 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T129929 WP_003407164.1 NZ_CP041799:1319069-1319890 [Mycobacterium tuberculosis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

>T129929 NZ_CP041799:1319069-1319890 [Mycobacterium tuberculosis]
GTGGTGGTAGCCCTCGTAGGCTCAGCAATCGTGGACTTGCATTCACGACCACCGTGGTCGAACAACGCGGTGCGTCGTCT
TGGCGTGGCACTGCGCGACGGAGTTGACCCGCCGGTCGACTGCCCGTCGTACGCCGAGGTGATGCTGTGGCATGCGGACT
TGGCCGCCGAAGTCCAGGACCGGATCGAGGGCCGGAGTTGGTCTGCGTCGGAGTTATTGGTTACCTCACGTGCGAAGAGC
CAAGACACCCTGCTAGCAAAGCTGCGGCGTCGGCCTTACCTGCAACTGAACACCATCCAAGACATCGCAGGTGTCCGCAT
CGATGCCGACCTCCTGCTGGGCGAGCAGACGAGACTTGCTCGCGAGATCGCCGACCACTTCGGTGCTGACCAGCCCGCTA
TTCATGATCTGCGTGACCACCCGCACGCCGGCTACCGGGCCGTTCATGTCTGGCTTCGGTTACCTGCCGGTCGTGTCGAG
ATACAGATTCGCACCATTTTGCAGAGCCTGTGGGCCAACTTCTACGAGCTTCTCGCTGACGCGTACGGTCGGGGCATCCG
CTATGACGAGCGGCCGGAGCAGCTAGCGGCCGGCGTTGTCCCGGCACAGCTTCAAGAGCTGGTAGGGGTTATGCAAGACG
CTTCAGCGGATCTGGCGATGCATGAAGCCGAGTGGCAACACTGTGCAGAGATCGAATACCCCGGCCAGCGGGCGATGGCG
CTTGGCGAGGCGAGCAAGAACAAGGCGACGGTGCTCGCAACGACCAAGTTTAGGCTGGAAAGGGCCATCAATGAGGCCGA
GTCGGCAGGGGGAGGTGGGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT129929 WP_003407167.1 NZ_CP041799:1319883-1320119 [Mycobacterium tuberculosis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp

>AT129929 NZ_CP041799:1319883-1320119 [Mycobacterium tuberculosis]
GTGGGTGAGGTGGCTGGCTATGTCGTCGAATACAACCGGCGCACCCACGTGCGTCGCATCACCGAGTTCGCCACCCCGCA
AGAAGCGATGGAGCACCGGTTGAAGCTGGAAGCCGAGCGCACCGACAGCAATATCGAGATCGTTGCGCTCGTCAGTAAGT
CGTTGGGAACCCTGAAGCAAACGCATTCGCGGTACTTCACTGGTGAAGAGCTGAACGTCGGAAACGGCGCGCGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBG0TIH2

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7U4BTV8

References