Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 676016..676635 Replicon chromosome
Accession NZ_CP041799
Organism Mycobacterium tuberculosis strain SEA13020298P6C4

Toxin (Protein)


Gene name vapC Uniprot ID O53779
Locus tag FPK10_RS03035 Protein ID WP_003403047.1
Coordinates 676228..676635 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O53778
Locus tag FPK10_RS03030 Protein ID WP_003403039.1
Coordinates 676016..676231 (+) Length 72 a.a.

Genomic Context

FPK10_RS03020FPK10_RS03030FPK10_RS03035FPK10_RS03045FPK10_RS03025FPK10_RS03040
Location: 674544..675302 (759 bp)
Type: Others
Protein ID: WP_003898511.1
Location: 676016..676231 (216 bp)
Type: Antitoxin
Protein ID: WP_003403039.1
Location: 676228..676635 (408 bp)
Type: Toxin
Protein ID: WP_003403047.1
Location: 677535..680168 (2634 bp)
Type: Others
Protein ID: WP_003403055.1
Location: 675431..675922 (492 bp)
Type: Others
Protein ID: WP_003403017.1
Location: 676695..677381 (687 bp)
Type: Others
Protein ID: WP_003403052.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FPK10_RS03020674544..675302+759WP_003898511.1Mut7-C ubiquitin/RNAse domain-containing protein-
FPK10_RS03025675431..675922-492WP_003403017.1hypothetical protein-
FPK10_RS03030676016..676231+216WP_003403039.1type II toxin-antitoxin system antitoxin VapB26Antitoxin
FPK10_RS03035676228..676635+408WP_003403047.1type II toxin-antitoxin system toxin ribonuclease C26Toxin
FPK10_RS03040676695..677381-687WP_003403052.1LpqN/LpqT family lipoprotein-
FPK10_RS03045677535..680168+2634WP_003403055.1GH92 family glycosyl hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-39)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14471.43 Da        Isoelectric Point: 4.4493

>T129921 WP_003403047.1 NZ_CP041799:676228-676635 [Mycobacterium tuberculosis]
VIIDTSALLAYFDAAEPDHAAVSECIDSSADALVVSPYVVAELDYLVATRVGVDAELAVLRELAGGAWELANCGAAEIEQ
AARIVTKYQDQRIGIADAANVVLADRYRTRTILTLDRRHFSALRPIGGGRFTVIP

Download         Length: 408 bp

>T129921 NZ_CP041799:676228-676635 [Mycobacterium tuberculosis]
GTGATCATCGACACGAGTGCGCTGCTTGCCTATTTCGACGCCGCCGAGCCAGACCACGCCGCAGTGTCTGAGTGCATCGA
TAGCTCCGCAGACGCGCTCGTCGTATCCCCTTATGTGGTAGCGGAACTCGACTATCTCGTCGCCACCCGGGTAGGTGTCG
ATGCCGAGCTCGCCGTCCTGCGTGAACTCGCCGGCGGGGCCTGGGAGCTCGCCAACTGCGGTGCCGCCGAAATCGAGCAG
GCCGCCCGCATCGTCACGAAATACCAGGATCAGCGGATCGGGATCGCGGATGCGGCCAACGTCGTGCTGGCCGACCGATA
CCGCACGCGCACGATCCTCACCCTGGACCGTCGGCACTTCTCGGCGCTGCGGCCGATCGGCGGTGGGCGCTTCACCGTCA
TTCCGTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7572.66 Da        Isoelectric Point: 10.5454

>AT129921 WP_003403039.1 NZ_CP041799:676016-676231 [Mycobacterium tuberculosis]
VDKTTVYLPDELKAAVKRAARQRGVSEAQVIRESIRAAVGGAKPPPRGGLYAGSEPIARRVDELLAGFGER

Download         Length: 216 bp

>AT129921 NZ_CP041799:676016-676231 [Mycobacterium tuberculosis]
GTGGACAAGACGACGGTCTACCTGCCGGATGAACTCAAGGCGGCCGTGAAGCGCGCCGCTCGGCAGCGCGGAGTCTCCGA
AGCGCAGGTAATCCGGGAGTCCATCCGGGCGGCGGTCGGCGGCGCCAAGCCGCCGCCGCGCGGGGGTCTATATGCGGGTT
CGGAGCCCATCGCGCGGCGAGTCGACGAGCTGCTGGCTGGCTTCGGTGAGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB5X3T

Antitoxin

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Source
ID
Structure
PDB5X3T
AlphaFold DBA0A7U4BSA2

References