Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
Location | 1960106..1960566 | Replicon | chromosome |
Accession | NZ_CP041798 | ||
Organism | Mycobacterium tuberculosis strain SEA13111P6C4 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TKL9 |
Locus tag | FPK11_RS09015 | Protein ID | WP_003898996.1 |
Coordinates | 1960318..1960566 (+) | Length | 83 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A806JZ84 |
Locus tag | FPK11_RS09010 | Protein ID | WP_003904688.1 |
Coordinates | 1960106..1960318 (+) | Length | 71 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FPK11_RS08995 | 1956584..1957771 | - | 1188 | WP_003898992.1 | nitrate transporter NarK | - |
FPK11_RS09000 | 1958058..1958342 | + | 285 | WP_003408522.1 | DUF1876 domain-containing protein | - |
FPK11_RS09005 | 1958356..1960038 | - | 1683 | WP_003898994.1 | SulP family inorganic anion transporter | - |
FPK11_RS09010 | 1960106..1960318 | + | 213 | WP_003904688.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
FPK11_RS09015 | 1960318..1960566 | + | 249 | WP_003898996.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
FPK11_RS09020 | 1960574..1961311 | + | 738 | WP_003898997.1 | hypothetical protein | - |
FPK11_RS09025 | 1961405..1963105 | + | 1701 | WP_003898998.1 | serine/threonine protein kinase PknE | - |
FPK11_RS09030 | 1963390..1963791 | - | 402 | WP_003408538.1 | hypothetical protein | - |
FPK11_RS09035 | 1963781..1964392 | - | 612 | WP_003898999.1 | isopentenyl-diphosphate Delta-isomerase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 83 a.a. Molecular weight: 8884.14 Da Isoelectric Point: 4.1074
>T129885 WP_003898996.1 NZ_CP041798:1960318-1960566 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG
Download Length: 249 bp
>T129885 NZ_CP041798:1960318-1960566 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA
Antitoxin
Download Length: 71 a.a. Molecular weight: 7577.77 Da Isoelectric Point: 9.3146
>AT129885 WP_003904688.1 NZ_CP041798:1960106-1960318 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRAGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA
MELAARMGETLTQAVVVAVREQLARRAGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA
Download Length: 213 bp
>AT129885 NZ_CP041798:1960106-1960318 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGGC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGGC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TKL9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A806JZ84 |