Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 714897..715522 Replicon chromosome
Accession NZ_CP041798
Organism Mycobacterium tuberculosis strain SEA13111P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag FPK11_RS03225 Protein ID WP_003403218.1
Coordinates 715121..715522 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag FPK11_RS03220 Protein ID WP_003403213.1
Coordinates 714897..715124 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK11_RS03195 710076..710297 - 222 WP_003898525.1 DUF4926 domain-containing protein -
FPK11_RS03200 710439..711044 + 606 WP_003898526.1 hypothetical protein -
FPK11_RS03205 711063..713630 - 2568 WP_193019588.1 SEC-C domain-containing protein -
FPK11_RS03210 713714..714463 + 750 WP_003898528.1 hypothetical protein -
FPK11_RS03215 714460..714702 + 243 WP_003403210.1 hypothetical protein -
FPK11_RS03220 714897..715124 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
FPK11_RS03225 715121..715522 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
FPK11_RS03230 715651..715734 + 84 Protein_640 galactose-1-phosphate uridylyltransferase -
FPK11_RS03235 715753..716835 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
FPK11_RS03240 716832..717923 + 1092 WP_003900977.1 galactokinase -
FPK11_RS03245 718318..719475 + 1158 WP_003903091.1 hypothetical protein -
FPK11_RS03250 719486..720433 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T129865 WP_003403218.1 NZ_CP041798:715121-715522 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T129865 NZ_CP041798:715121-715522 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTACGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT129865 WP_003403213.1 NZ_CP041798:714897-715124 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT129865 NZ_CP041798:714897-715124 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References