Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 644315..644991 Replicon chromosome
Accession NZ_CP041798
Organism Mycobacterium tuberculosis strain SEA13111P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TPQ9
Locus tag FPK11_RS02870 Protein ID WP_003898500.1
Coordinates 644315..644728 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TPR0
Locus tag FPK11_RS02875 Protein ID WP_003402915.1
Coordinates 644725..644991 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK11_RS02840 639660..639962 - 303 WP_003402896.1 DUF3349 domain-containing protein -
FPK11_RS02845 640022..640300 - 279 WP_003402901.1 hypothetical protein -
FPK11_RS02850 640297..641550 - 1254 WP_003402904.1 inorganic phosphate transporter family protein -
FPK11_RS02855 641670..642056 - 387 WP_003402907.1 VOC family protein -
FPK11_RS02860 642119..643003 - 885 WP_003402909.1 SDR family oxidoreductase -
FPK11_RS02865 643099..644001 - 903 WP_003915439.1 1,4-dihydroxy-2-naphthoyl-CoA synthase -
FPK11_RS02870 644315..644728 - 414 WP_003898500.1 PIN domain-containing protein Toxin
FPK11_RS02875 644725..644991 - 267 WP_003402915.1 antitoxin VapB3 Antitoxin
FPK11_RS02880 645183..646898 - 1716 WP_003402917.1 fatty-acid--CoA ligase FadD8 -
FPK11_RS02885 646976..648580 + 1605 WP_003903056.1 amidohydrolase -
FPK11_RS02890 648577..649557 + 981 WP_003402923.1 o-succinylbenzoate synthase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-129)

Antitoxin

(19-61)


Sequences


Toxin        


Download         Length: 138 a.a.        Molecular weight: 14667.78 Da        Isoelectric Point: 7.3603

>T129860 WP_003898500.1 NZ_CP041798:c644728-644315 [Mycobacterium tuberculosis]
VRASPTSPPEQVVVDASAMVDLLARTSDRCSAVRARLARTAMHAPAHFDAEVLSALGRMQRAGALTVAYVDAALEELRQV
PVTRHGLSSLLAGAWSRRDTLRLTDALYVELAETAGLVLLTTDERLARAWPSAHAIG

Download         Length: 414 bp

>T129860 NZ_CP041798:c644728-644315 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9543.79 Da        Isoelectric Point: 4.5994

>AT129860 WP_003402915.1 NZ_CP041798:c644991-644725 [Mycobacterium tuberculosis]
MLSRRTKTIVVCTLVCMARLNVYVPDELAERARARGLNVSALTQAAISAELENSATDAWLEGLEPRSTGARHDDVLGAID
AARDEFEA

Download         Length: 267 bp

>AT129860 NZ_CP041798:c644991-644725 [Mycobacterium tuberculosis]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TPQ9


Antitoxin

Source ID Structure
AlphaFold DB G0TPR0

References