Detailed information of TA system TA129807

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 748988..749621
• Replicon: chromosome
• Accession: NZ_CP041797
• Organism: Mycobacterium tuberculosis strain SEA14117P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FPK12_RS03420
• Protein ID: WP_031684091.1
• Coordinates: 748988..749371 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P9WJ56
• Locus tag: FPK12_RS03425
• Protein ID: WP_003403368.1
• Coordinates: 749466..749621 (-)
• Length: 52 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPK12_RS03395	744280..744816	+	537	WP_003403341.1	50S ribosomal protein L10	-
FPK12_RS03400	744853..745245	+	393	WP_003900989.1	50S ribosomal protein L7/L12	-
FPK12_RS03405	745238..745933	-	696	WP_003403355.1	TetR/AcrR family transcriptional regulator	-
FPK12_RS03410	746004..747509	+	1506	WP_003403360.1	carotenoid cleavage oxygenase	-
FPK12_RS03415	747590..748600	+	1011	WP_003911248.1	ABC transporter ATP-binding protein	-
FPK12_RS03420	748988..749371	-	384	WP_031684091.1	ribonuclease	Toxin
FPK12_RS03425	749466..749621	-	156	WP_003403368.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FPK12_RS03430	749697..750413	-	717	WP_003403371.1	CPBP family intramembrane metalloprotease	-
FPK12_RS03435	750689..750997	-	309	WP_003403376.1	type II toxin-antitoxin system PemK/MazF family toxin	-
FPK12_RS03440	750984..751229	-	246	WP_003403381.1	ribbon-helix-helix protein, CopG family	-
FPK12_RS03445	751339..751776	-	438	WP_003403386.1	type II toxin-antitoxin system VapC family toxin	-
FPK12_RS03450	751773..752027	-	255	WP_003911263.1	antitoxin VapB7	-
FPK12_RS03455	752141..754504	+	2364	WP_003901895.1	arylsulfatase AtsD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-44)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 13931.68 Da
• Isoelectric Point: 6.0803

>T129807 WP_031684091.1 NZ_CP041797:c749371-748988 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDAPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Nucleotide

• Length: 384 bp

>T129807 NZ_CP041797:c749371-748988 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGCGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin

Protein

• Length: 52 a.a.
• Molecular weight: 5872.72 Da
• Isoelectric Point: 5.7734

>AT129807 WP_003403368.1 NZ_CP041797:c749621-749466 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Nucleotide

• Length: 156 bp

>AT129807 NZ_CP041797:c749621-749466 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A7U4BSF8