Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 73252..73885 Replicon chromosome
Accession NZ_CP041797
Organism Mycobacterium tuberculosis strain SEA14117P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P9WFC0
Locus tag FPK12_RS00360 Protein ID WP_003400580.1
Coordinates 73484..73885 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P0CW29
Locus tag FPK12_RS00355 Protein ID WP_003400577.1
Coordinates 73252..73491 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK12_RS00340 68549..69988 + 1440 WP_003901784.1 FAD-binding oxidoreductase -
FPK12_RS00345 70044..70205 + 162 WP_003899796.1 hypothetical protein -
FPK12_RS00350 70246..73185 + 2940 WP_003901785.1 UPF0182 family protein -
FPK12_RS00355 73252..73491 + 240 WP_003400577.1 antitoxin VapB1 Antitoxin
FPK12_RS00360 73484..73885 + 402 WP_003400580.1 type II toxin-antitoxin system ribonuclease VapC1 Toxin
FPK12_RS00365 73937..76174 - 2238 WP_003899797.1 NADP-dependent isocitrate dehydrogenase -
FPK12_RS00370 76292..76861 - 570 WP_003400591.1 TetR/AcrR family transcriptional regulator; helix-turn-helix transcriptional regulator -
FPK12_RS00375 76964..77884 + 921 WP_003901786.1 SDR family NAD(P)-dependent oxidoreductase -
FPK12_RS00380 77820..78161 + 342 Protein_72 pyridoxal phosphate-dependent aminotransferase -
FPK12_RS00385 78176..78556 - 381 WP_003913085.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(36-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14339.44 Da        Isoelectric Point: 4.8887

>T129794 WP_003400580.1 NZ_CP041797:73484-73885 [Mycobacterium tuberculosis]
VDECVVDAAAVVDALAGKGASAIVLRGLLKESISNAPHLLDAEVGHALRRAVLSDEISEEQARAALDALPYLIDNRYPHS
PRLIEYTWQLRHNVTFYDALYVALATALDVPLLTGDSRLAAAPGLPCEIKLVR

Download         Length: 402 bp

>T129794 NZ_CP041797:73484-73885 [Mycobacterium tuberculosis]
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGGAGTCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8717.84 Da        Isoelectric Point: 8.5960

>AT129794 WP_003400577.1 NZ_CP041797:73252-73491 [Mycobacterium tuberculosis]
MATIQVRDLPEDVAETYRRRATAAGQSLQTYMRTKLIEGVRGRDKAEAIEILEQALASTASPGISRETIEASRRELRGG

Download         Length: 240 bp

>AT129794 NZ_CP041797:73252-73491 [Mycobacterium tuberculosis]
ATGGCTACCATTCAAGTTCGGGATTTGCCCGAAGATGTCGCCGAAACCTATCGACGGCGCGCCACCGCAGCGGGGCAGTC
GCTGCAGACGTATATGCGCACCAAGCTCATCGAAGGGGTGCGGGGCCGAGACAAGGCCGAGGCAATCGAGATCCTGGAAC
AGGCGCTCGCCAGCACTGCCAGCCCAGGCATCAGCCGGGAGACCATCGAGGCATCCCGGCGGGAGCTCAGGGGTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BR82

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHM7

References