129774

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2412549..2413078 Replicon chromosome
Accession NZ_CP041796
Organism Mycobacterium tuberculosis strain SEA14318P6C4

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag FPK13_RS11140 Protein ID WP_003411124.1
Coordinates 2412549..2412866 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag FPK13_RS11145 Protein ID WP_003411127.1
Coordinates 2412863..2413078 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK13_RS11110 2407687..2408763 + 1077 WP_003904789.1 hypothetical protein -
FPK13_RS11115 2408760..2409041 + 282 WP_003411112.1 hypothetical protein -
FPK13_RS11120 2409077..2410150 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
FPK13_RS11125 2410155..2410685 - 531 WP_003903767.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
FPK13_RS11130 2410733..2412079 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
FPK13_RS11140 2412549..2412866 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FPK13_RS11145 2412863..2413078 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
FPK13_RS11150 2413333..2414391 + 1059 WP_003411129.1 hypothetical protein -
FPK13_RS11155 2414521..2414877 - 357 WP_003411130.1 hypothetical protein -
FPK13_RS11160 2414972..2415754 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
FPK13_RS11165 2416022..2416312 - 291 WP_003900476.1 YggT family protein -
FPK13_RS11170 2416474..2417130 - 657 WP_193019222.1 cell division protein SepF -
FPK13_RS11175 2417196..2417972 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T129774 WP_003411124.1 NZ_CP041796:c2412866-2412549 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T129774 NZ_CP041796:c2412866-2412549 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT129774 WP_003411127.1 NZ_CP041796:c2413078-2412863 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT129774 NZ_CP041796:c2413078-2412863 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References