Detailed information of TA system TA129767

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 2232191..2232879
• Replicon: chromosome
• Accession: NZ_CP041796
• Organism: Mycobacterium tuberculosis strain SEA14318P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P0A653
• Locus tag: FPK13_RS10295
• Protein ID: WP_003409958.1
• Coordinates: 2232191..2232610 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FPK13_RS10300
• Protein ID: WP_193019217.1
• Coordinates: 2232619..2232879 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPK13_RS10275	2227686..2228534	+	849	WP_003409942.1	class I SAM-dependent methyltransferase	-
FPK13_RS10280	2228497..2229942	-	1446	WP_003409946.1	APC family permease	-
FPK13_RS10285	2230121..2230807	-	687	WP_014588466.1	immunoprotective protein Mpt64	-
FPK13_RS10290	2230998..2231966	-	969	WP_003899116.1	class 1b ribonucleoside-diphosphate reductase subunit beta	-
FPK13_RS10295	2232191..2232610	-	420	WP_003409958.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPK13_RS10300	2232619..2232879	-	261	WP_193019217.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FPK13_RS10305	2233022..2234698	+	1677	WP_003899118.1	PecA family PE domain-processing aspartic protease	-
FPK13_RS10310	2234686..2235339	-	654	WP_003409976.1	cutinase Cfp21	-
FPK13_RS10315	2235454..2235684	+	231	WP_003409980.1	DUF167 domain-containing protein	-
FPK13_RS10320	2235769..2236680	-	912	WP_003409986.1	ArgP/LysG family DNA-binding transcriptional regulator	-
FPK13_RS10325	2236789..2237388	+	600	WP_003409989.1	L-lysine exporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-125)

Antitoxin

• Antitoxin VapB-like (2-81)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14724.89 Da
• Isoelectric Point: 7.9535

>T129767 WP_003409958.1 NZ_CP041796:c2232610-2232191 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Nucleotide

• Length: 420 bp

>T129767 NZ_CP041796:c2232610-2232191 [Mycobacterium tuberculosis]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9542.91 Da
• Isoelectric Point: 5.1007

>AT129767 WP_193019217.1 NZ_CP041796:c2232879-2232619 [Mycobacterium tuberculosis]
VALNIKDPEIDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Nucleotide

• Length: 261 bp

>AT129767 NZ_CP041796:c2232879-2232619 [Mycobacterium tuberculosis]
GTGGCGCTGAATATCAAAGACCCTGAGATAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Structures

Toxin

• AlphaFold DB: A0A829C4H9