129749

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 758962..759650 Replicon chromosome
Accession NZ_CP041796
Organism Mycobacterium tuberculosis strain SEA14318P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag FPK13_RS03475 Protein ID WP_003403386.1
Coordinates 758962..759399 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O06777
Locus tag FPK13_RS03480 Protein ID WP_003911263.1
Coordinates 759396..759650 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK13_RS03445 755213..756223 + 1011 WP_031653722.1 ABC transporter ATP-binding protein -
FPK13_RS03450 756611..756994 - 384 WP_003403365.1 ribonuclease VapC6 -
FPK13_RS03455 757089..757244 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
FPK13_RS03460 757320..758036 - 717 WP_003903122.1 CPBP family intramembrane metalloprotease -
FPK13_RS03465 758312..758620 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
FPK13_RS03470 758607..758852 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
FPK13_RS03475 758962..759399 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
FPK13_RS03480 759396..759650 - 255 WP_003911263.1 antitoxin VapB7 Antitoxin
FPK13_RS03485 759764..762127 + 2364 WP_003403397.1 arylsulfatase AtsD -
FPK13_RS03490 762190..762516 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPK13_RS03495 762428..762766 + 339 WP_003403405.1 PIN domain-containing protein -
FPK13_RS03500 762763..762936 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T129749 WP_003403386.1 NZ_CP041796:c759399-758962 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T129749 NZ_CP041796:c759399-758962 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9450.99 Da        Isoelectric Point: 11.7073

>AT129749 WP_003911263.1 NZ_CP041796:c759650-759396 [Mycobacterium tuberculosis]
MSMRLAHRLQILLDDECHRRITAVARERGVPVATVVREAIDRGLVSPAGRRKSAGRRLLDAADMSVPEPRELKQELEALR
ARRG

Download         Length: 255 bp

>AT129749 NZ_CP041796:c759650-759396 [Mycobacterium tuberculosis]
ATGAGCATGCGTCTGGCGCATCGGCTCCAGATCCTGCTCGACGACGAGTGCCACCGCCGCATCACCGCGGTGGCGCGCGA
GCGAGGCGTCCCGGTCGCAACCGTCGTGCGTGAGGCCATTGATCGAGGCCTCGTCAGCCCCGCCGGTCGCCGCAAGTCCG
CGGGCAGGCGCCTGCTCGACGCCGCCGACATGTCCGTTCCCGAGCCGCGGGAGCTGAAGCAGGAACTCGAGGCCCTCCGG
GCGCGCCGCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB A0A806JQG1

References