Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3770927..3771456 Replicon chromosome
Accession NZ_CP041795
Organism Mycobacterium tuberculosis strain SEA14333P6C4

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag FPK14_RS17485 Protein ID WP_003417760.1
Coordinates 3771199..3771456 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag FPK14_RS17480 Protein ID WP_003417757.1
Coordinates 3770927..3771202 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK14_RS17460 3767725..3769162 - 1438 Protein_3448 FAD-binding oxidoreductase -
FPK14_RS17465 3769265..3769654 + 390 WP_003417745.1 DUF732 domain-containing protein -
FPK14_RS17470 3769668..3769961 - 294 WP_031663850.1 DUF3017 domain-containing protein -
FPK14_RS17475 3769958..3770803 - 846 WP_003905054.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
FPK14_RS17480 3770927..3771202 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
FPK14_RS17485 3771199..3771456 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
FPK14_RS17490 3771498..3772688 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
FPK14_RS17495 3772805..3773173 + 369 WP_003417765.1 FHA domain-containing protein -
FPK14_RS17500 3773170..3773721 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
FPK14_RS17505 3773728..3774309 - 582 WP_031662192.1 ATP/GTP-binding protein -
FPK14_RS17510 3774290..3774658 - 369 WP_003417772.1 DUF742 domain-containing protein -
FPK14_RS17515 3774636..3775028 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T129730 WP_003417760.1 NZ_CP041795:3771199-3771456 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T129730 NZ_CP041795:3771199-3771456 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT129730 WP_003417757.1 NZ_CP041795:3770927-3771202 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT129730 NZ_CP041795:3770927-3771202 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References