Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2940350..2941064 Replicon chromosome
Accession NZ_CP041795
Organism Mycobacterium tuberculosis strain SEA14333P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag FPK14_RS13600 Protein ID WP_003413460.1
Coordinates 2940624..2941064 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag FPK14_RS13595 Protein ID WP_003413456.1
Coordinates 2940350..2940637 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK14_RS13560 2935772..2936017 + 246 WP_031663784.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
FPK14_RS13565 2936014..2936418 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
FPK14_RS13570 2936635..2937255 + 621 WP_003413441.1 DUF4178 domain-containing protein -
FPK14_RS13575 2937266..2937760 + 495 WP_003413444.1 DUF2617 family protein -
FPK14_RS13580 2937757..2938188 + 432 WP_003413445.1 DUF4247 domain-containing protein -
FPK14_RS13585 2938213..2938671 + 459 WP_003413451.1 DUF350 domain-containing protein -
FPK14_RS13590 2938668..2940239 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
FPK14_RS13595 2940350..2940637 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
FPK14_RS13600 2940624..2941064 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
FPK14_RS13605 2941085..2941840 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
FPK14_RS13610 2941973..2942569 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
FPK14_RS13615 2942577..2943422 - 846 WP_003413466.1 acyl-CoA thioesterase II -
FPK14_RS13620 2943451..2944350 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
FPK14_RS13625 2944478..2945152 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T129720 WP_003413460.1 NZ_CP041795:2940624-2941064 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T129720 NZ_CP041795:2940624-2941064 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT129720 WP_003413456.1 NZ_CP041795:2940350-2940637 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT129720 NZ_CP041795:2940350-2940637 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References