Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3770742..3771271 Replicon chromosome
Accession NZ_CP041794
Organism Mycobacterium tuberculosis strain SEA15228P6C4

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag FPK16_RS17480 Protein ID WP_003417760.1
Coordinates 3771014..3771271 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag FPK16_RS17475 Protein ID WP_003417757.1
Coordinates 3770742..3771017 (+) Length 92 a.a.

Genomic Context

FPK16_RS17460FPK16_RS17475FPK16_RS17480FPK16_RS17485FPK16_RS17490FPK16_RS17455FPK16_RS17465FPK16_RS17470FPK16_RS17495FPK16_RS17500FPK16_RS17505FPK16_RS17510
Location: 3769080..3769469 (390 bp)
Type: Others
Protein ID: WP_003417745.1
Location: 3770742..3771017 (276 bp)
Type: Antitoxin
Protein ID: WP_003417757.1
Location: 3771014..3771271 (258 bp)
Type: Toxin
Protein ID: WP_003417760.1
Location: 3771313..3772503 (1191 bp)
Type: Others
Protein ID: WP_003900033.1
Location: 3772620..3772988 (369 bp)
Type: Others
Protein ID: WP_003417765.1
Location: 3767540..3768977 (1438 bp)
Type: Others
Protein ID: Protein_3447
Location: 3769483..3769776 (294 bp)
Type: Others
Protein ID: WP_031663850.1
Location: 3769773..3770618 (846 bp)
Type: Others
Protein ID: WP_003905054.1
Location: 3772985..3773536 (552 bp)
Type: Others
Protein ID: WP_003417767.1
Location: 3773543..3774124 (582 bp)
Type: Others
Protein ID: WP_031662192.1
Location: 3774105..3774473 (369 bp)
Type: Others
Protein ID: WP_003417772.1
Location: 3774451..3774843 (393 bp)
Type: Others
Protein ID: WP_003417776.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FPK16_RS174553767540..3768977-1438Protein_3447FAD-binding oxidoreductase-
FPK16_RS174603769080..3769469+390WP_003417745.1DUF732 domain-containing protein-
FPK16_RS174653769483..3769776-294WP_031663850.1DUF3017 domain-containing protein-
FPK16_RS174703769773..3770618-846WP_003905054.1bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase-
FPK16_RS174753770742..3771017+276WP_003417757.1type II toxin-antitoxin system antitoxin RelJAntitoxin
FPK16_RS174803771014..3771271+258WP_003417760.1Txe/YoeB family addiction module toxinToxin
FPK16_RS174853771313..3772503+1191WP_003900033.1NADH:flavin oxidoreductase-
FPK16_RS174903772620..3772988+369WP_003417765.1FHA domain-containing protein-
FPK16_RS174953772985..3773536-552WP_003417767.1pentapeptide repeat protein MfpA-
FPK16_RS175003773543..3774124-582WP_031662192.1ATP/GTP-binding protein-
FPK16_RS175053774105..3774473-369WP_003417772.1DUF742 domain-containing protein-
FPK16_RS175103774451..3774843-393WP_003417776.1roadblock/LC7 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T129671 WP_003417760.1 NZ_CP041794:3771014-3771271 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T129671 NZ_CP041794:3771014-3771271 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT129671 WP_003417757.1 NZ_CP041794:3770742-3771017 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT129671 NZ_CP041794:3770742-3771017 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB3OEI

Antitoxin

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Source
ID
Structure
PDB3CTO
PDB3OEI
PDB3D55
AlphaFold DBG0TI94

References