Detailed information of TA system TA129670

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3704811..3705485
• Replicon: chromosome
• Accession: NZ_CP041794
• Organism: Mycobacterium tuberculosis strain SEA15228P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P9WF52
• Locus tag: FPK16_RS17290
• Protein ID: WP_003417282.1
• Coordinates: 3704811..3705239 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TI59
• Locus tag: FPK16_RS17295
• Protein ID: WP_003417286.1
• Coordinates: 3705243..3705485 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPK16_RS17265	3700633..3701034	-	402	WP_003417264.1	cytidine deaminase	-
FPK16_RS17270	3701175..3701609	+	435	WP_072460198.1	succinate dehydrogenase, cytochrome b556 subunit	-
FPK16_RS17275	3701606..3702040	+	435	WP_003417269.1	succinate dehydrogenase hydrophobic membrane anchor subunit	-
FPK16_RS17280	3702169..3703941	+	1773	WP_003417273.1	succinate dehydrogenase flavoprotein subunit	-
FPK16_RS17285	3703941..3704732	+	792	WP_003417279.1	succinate dehydrogenase iron-sulfur subunit	-
FPK16_RS17290	3704811..3705239	-	429	WP_003417282.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPK16_RS17295	3705243..3705485	-	243	WP_003417286.1	ribbon-helix-helix domain-containing protein	Antitoxin
FPK16_RS17300	3705607..3706221	-	615	WP_003417288.1	class I SAM-dependent methyltransferase	-
FPK16_RS17305	3706218..3706883	-	666	WP_003417290.1	molybdopterin converting factor subunit 1	-
FPK16_RS17310	3706884..3707417	-	534	WP_193019453.1	cyclic pyranopterin monophosphate synthase MoaC	-
FPK16_RS17315	3707414..3707788	-	375	WP_003417295.1	4a-hydroxytetrahydrobiopterin dehydratase	-
FPK16_RS17320	3707885..3708949	-	1065	WP_003913037.1	GTP 3',8-cyclase MoaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-141)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15834.16 Da
• Isoelectric Point: 8.5471

>T129670 WP_003417282.1 NZ_CP041794:c3705239-3704811 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Nucleotide

• Length: 429 bp

>T129670 NZ_CP041794:c3705239-3704811 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8849.86 Da
• Isoelectric Point: 5.1007

>AT129670 WP_003417286.1 NZ_CP041794:c3705485-3705243 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Nucleotide

• Length: 243 bp

>AT129670 NZ_CP041794:c3705485-3705243 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Structures

Toxin

• AlphaFold DB: A0A7U4FBL0

Antitoxin

• AlphaFold DB: G0TI59