Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1938661..1939274 Replicon chromosome
Accession NZ_CP041794
Organism Mycobacterium tuberculosis strain SEA15228P6C4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FPK16_RS08910 Protein ID WP_193019527.1
Coordinates 1938661..1939050 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag FPK16_RS08915 Protein ID WP_003408469.1
Coordinates 1939047..1939274 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK16_RS08880 1934290..1935204 + 915 WP_031663714.1 3-hydroxyacyl-CoA dehydrogenase family protein -
FPK16_RS08885 1935207..1936037 + 831 WP_003408448.1 cyclase family protein -
FPK16_RS08890 1936037..1936387 + 351 WP_003898986.1 cupin domain-containing protein -
FPK16_RS08895 1936440..1937258 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
FPK16_RS08900 1937272..1938051 + 780 WP_003408460.1 IclR family transcriptional regulator -
FPK16_RS08910 1938661..1939050 - 390 WP_193019527.1 PIN domain-containing protein Toxin
FPK16_RS08915 1939047..1939274 - 228 WP_003408469.1 antitoxin Antitoxin
FPK16_RS08920 1939492..1940976 + 1485 WP_003408473.1 carboxylase -
FPK16_RS08925 1940973..1942220 + 1248 WP_003408476.1 serine hydrolase -
FPK16_RS08930 1942263..1942682 - 420 WP_031663715.1 hypothetical protein -
FPK16_RS08935 1942672..1943382 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(3-117)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13764.93 Da        Isoelectric Point: 6.7489

>T129643 WP_193019527.1 NZ_CP041794:c1939050-1938661 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QCAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T129643 NZ_CP041794:c1939050-1938661 [Mycobacterium tuberculosis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGTGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT129643 WP_003408469.1 NZ_CP041794:c1939274-1939047 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT129643 NZ_CP041794:c1939274-1939047 [Mycobacterium tuberculosis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References