Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1241093..1241661 Replicon chromosome
Accession NZ_CP041794
Organism Mycobacterium tuberculosis strain SEA15228P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TH08
Locus tag FPK16_RS05845 Protein ID WP_003405865.1
Coordinates 1241287..1241661 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TH07
Locus tag FPK16_RS05840 Protein ID WP_003405863.1
Coordinates 1241093..1241290 (+) Length 66 a.a.

Genomic Context

FPK16_RS05825FPK16_RS05835FPK16_RS05840FPK16_RS05845FPK16_RS05850FPK16_RS05855FPK16_RS05865FPK16_RS05875FPK16_RS05820FPK16_RS05830FPK16_RS05860FPK16_RS05870FPK16_RS05880
Location: 1237862..1238869 (1008 bp)
Type: Others
Protein ID: WP_003405853.1
Location: 1239932..1241005 (1074 bp)
Type: Others
Protein ID: WP_003898732.1
Location: 1241093..1241290 (198 bp)
Type: Antitoxin
Protein ID: WP_003405863.1
Location: 1241287..1241661 (375 bp)
Type: Toxin
Protein ID: WP_003405865.1
Location: 1241864..1242562 (699 bp)
Type: Others
Protein ID: WP_003898733.1
Location: 1242680..1242865 (186 bp)
Type: Others
Protein ID: WP_003901093.1
Location: 1243310..1243633 (324 bp)
Type: Others
Protein ID: WP_003405871.1
Location: 1244380..1244589 (210 bp)
Type: Others
Protein ID: WP_003911400.1
Location: 1237134..1237772 (639 bp)
Type: Others
Protein ID: WP_003898730.1
Location: 1238886..1239869 (984 bp)
Type: Others
Protein ID: WP_003903326.1
Location: 1242792..1243067 (276 bp)
Type: Others
Protein ID: WP_003405867.1
Location: 1243648..1244358 (711 bp)
Type: Others
Protein ID: WP_003911399.1
Location: 1244541..1245248 (708 bp)
Type: Others
Protein ID: Protein_1158
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FPK16_RS058201237134..1237772-639WP_003898730.1lipid droplet-associated protein-
FPK16_RS058251237862..1238869+1008WP_003405853.14-hydroxy-3-methylbut-2-enyl diphosphate reductase-
FPK16_RS058301238886..1239869-984WP_003903326.1hypothetical protein-
FPK16_RS058351239932..1241005+1074WP_003898732.1redox-regulated ATPase YchF-
FPK16_RS058401241093..1241290+198WP_003405863.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
FPK16_RS058451241287..1241661+375WP_003405865.1type II toxin-antitoxin system VapC family toxinToxin
FPK16_RS058501241864..1242562+699WP_003898733.1hypothetical protein-
FPK16_RS058551242680..1242865+186WP_003901093.1hypothetical protein-
FPK16_RS058601242792..1243067-276WP_003405867.1hypothetical protein-
FPK16_RS058651243310..1243633+324WP_003405871.1antibiotic biosynthesis monooxygenase-
FPK16_RS058701243648..1244358-711WP_003911399.1hypothetical protein-
FPK16_RS058751244380..1244589+210WP_003911400.1hypothetical protein-
FPK16_RS058801244541..1245248-708Protein_1158adenylate/guanylate cyclase domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-111)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13444.56 Da        Isoelectric Point: 5.1881

>T129636 WP_003405865.1 NZ_CP041794:1241287-1241661 [Mycobacterium tuberculosis]
VILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGR
GLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS

Download         Length: 375 bp

>T129636 NZ_CP041794:1241287-1241661 [Mycobacterium tuberculosis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6973.03 Da        Isoelectric Point: 11.7327

>AT129636 WP_003405863.1 NZ_CP041794:1241093-1241290 [Mycobacterium tuberculosis]
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR

Download         Length: 198 bp

>AT129636 NZ_CP041794:1241093-1241290 [Mycobacterium tuberculosis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBG0TH08

Antitoxin

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Source
ID
Structure
AlphaFold DBG0TH07

References