Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3718454..3719128 Replicon chromosome
Accession NZ_CP041793
Organism Mycobacterium tuberculosis strain SEA15229P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag FPK17_RS17350 Protein ID WP_003417282.1
Coordinates 3718454..3718882 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag FPK17_RS17355 Protein ID WP_003417286.1
Coordinates 3718886..3719128 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK17_RS17325 3714276..3714677 - 402 WP_003417264.1 cytidine deaminase -
FPK17_RS17330 3714818..3715252 + 435 WP_072460198.1 succinate dehydrogenase, cytochrome b556 subunit -
FPK17_RS17335 3715249..3715683 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
FPK17_RS17340 3715812..3717584 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
FPK17_RS17345 3717584..3718375 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
FPK17_RS17350 3718454..3718882 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
FPK17_RS17355 3718886..3719128 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
FPK17_RS17360 3719250..3719864 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
FPK17_RS17365 3719861..3720526 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
FPK17_RS17370 3720527..3721060 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
FPK17_RS17375 3721057..3721431 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
FPK17_RS17380 3721528..3722592 - 1065 WP_003913037.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T129611 WP_003417282.1 NZ_CP041793:c3718882-3718454 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T129611 NZ_CP041793:c3718882-3718454 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT129611 WP_003417286.1 NZ_CP041793:c3719128-3718886 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT129611 NZ_CP041793:c3719128-3718886 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References