129605

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3123059..3123629 Replicon chromosome
Accession NZ_CP041793
Organism Mycobacterium tuberculosis strain SEA15229P6C4

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag FPK17_RS14650 Protein ID WP_003414166.1
Coordinates 3123059..3123415 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag FPK17_RS14655 Protein ID WP_003901465.1
Coordinates 3123399..3123629 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK17_RS14630 3118508..3120196 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
FPK17_RS14635 3120200..3120526 - 327 WP_003414157.1 hypothetical protein -
FPK17_RS14640 3120699..3121289 + 591 WP_031656198.1 DUF3558 family protein -
FPK17_RS14645 3121308..3122957 + 1650 WP_003899485.1 CocE/NonD family hydrolase -
FPK17_RS14650 3123059..3123415 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
FPK17_RS14655 3123399..3123629 - 231 WP_003901465.1 antitoxin MazE Antitoxin
FPK17_RS14660 3123672..3124715 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
FPK17_RS14665 3124906..3125181 + 276 WP_003911993.1 DUF1778 domain-containing protein -
FPK17_RS14670 3125357..3125611 - 255 WP_003917684.1 hypothetical protein -
FPK17_RS14675 3125759..3126163 + 405 WP_003414181.1 hypothetical protein -
FPK17_RS14680 3126160..3126351 + 192 WP_003414184.1 hypothetical protein -
FPK17_RS14685 3126415..3127704 + 1290 Protein_2898 transposase family protein -
FPK17_RS14690 3127938..3128195 + 258 WP_003899489.1 hypothetical protein -
FPK17_RS14695 3128300..3128611 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T129605 WP_003414166.1 NZ_CP041793:c3123415-3123059 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

>T129605 NZ_CP041793:c3123415-3123059 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT129605 WP_003901465.1 NZ_CP041793:c3123629-3123399 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp

>AT129605 NZ_CP041793:c3123629-3123399 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FBW3

References