Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2892349..2892980 Replicon chromosome
Accession NZ_CP041793
Organism Mycobacterium tuberculosis strain SEA15229P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ28
Locus tag FPK17_RS13405 Protein ID WP_003413174.1
Coordinates 2892603..2892980 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag FPK17_RS13400 Protein ID WP_003413167.1
Coordinates 2892349..2892606 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK17_RS13365 2887607..2887921 + 315 WP_009937839.1 hypothetical protein -
FPK17_RS13370 2888217..2889428 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
FPK17_RS13375 2889555..2890214 + 660 WP_003900846.1 LppA family lipoprotein -
FPK17_RS13380 2890211..2890870 + 660 WP_024456011.1 hypothetical protein -
FPK17_RS13385 2890867..2891529 + 663 WP_003900848.1 hypothetical protein -
FPK17_RS13390 2891526..2891804 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
FPK17_RS13395 2891897..2892310 + 414 WP_003413164.1 PIN domain nuclease -
FPK17_RS13400 2892349..2892606 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
FPK17_RS13405 2892603..2892980 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin Toxin
FPK17_RS13410 2892996..2893370 - 375 WP_003413177.1 hypothetical protein -
FPK17_RS13415 2893470..2893865 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
FPK17_RS13420 2893862..2894107 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
FPK17_RS13425 2894518..2894937 - 420 WP_003413190.1 A24 family peptidase -
FPK17_RS13430 2894949..2895758 - 810 WP_003413193.1 shikimate dehydrogenase -
FPK17_RS13435 2895755..2897008 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
FPK17_RS13440 2897001..2897513 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13728.72 Da        Isoelectric Point: 4.4687

>T129600 WP_003413174.1 NZ_CP041793:2892603-2892980 [Mycobacterium tuberculosis]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY

Download         Length: 378 bp

>T129600 NZ_CP041793:2892603-2892980 [Mycobacterium tuberculosis]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT129600 WP_003413167.1 NZ_CP041793:2892349-2892606 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT129600 NZ_CP041793:2892349-2892606 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ28

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References