Detailed information of TA system TA129598

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2877353..2877993
• Replicon: chromosome
• Accession: NZ_CP041793
• Organism: Mycobacterium tuberculosis strain SEA15229P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ08
• Locus tag: FPK17_RS13305
• Protein ID: WP_003412970.1
• Coordinates: 2877353..2877772 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ09
• Locus tag: FPK17_RS13310
• Protein ID: WP_003412975.1
• Coordinates: 2877769..2877993 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPK17_RS13275	2872938..2873660	-	723	WP_003412957.1	DUF1906 domain-containing protein	-
FPK17_RS13280	2874177..2874404	+	228	WP_003412960.1	type II toxin-antitoxin system VapB family antitoxin	-
FPK17_RS13285	2874401..2874802	+	402	WP_003412963.1	PIN domain-containing protein	-
FPK17_RS13290	2874837..2875757	-	921	WP_003412965.1	restriction endonuclease	-
FPK17_RS13295	2876098..2876343	-	246	WP_071854223.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
FPK17_RS13300	2876402..2877352	+	951	WP_003911916.1	Lsr2 family protein	-
FPK17_RS13305	2877353..2877772	-	420	WP_003412970.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPK17_RS13310	2877769..2877993	-	225	WP_003412975.1	antitoxin VapB39	Antitoxin
FPK17_RS13315	2878025..2880868	-	2844	WP_003904863.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
FPK17_RS13320	2880940..2881341	-	402	WP_003412981.1	hypothetical protein	-
FPK17_RS13325	2881341..2881811	-	471	WP_003412985.1	transcription antitermination factor NusB	-
FPK17_RS13330	2881814..2882377	-	564	WP_003412989.1	elongation factor P	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14732.70 Da
• Isoelectric Point: 6.7519

>T129598 WP_003412970.1 NZ_CP041793:c2877772-2877353 [Mycobacterium tuberculosis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Nucleotide

• Length: 420 bp

>T129598 NZ_CP041793:c2877772-2877353 [Mycobacterium tuberculosis]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 7993.94 Da
• Isoelectric Point: 4.0057

>AT129598 WP_003412975.1 NZ_CP041793:c2877993-2877769 [Mycobacterium tuberculosis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Nucleotide

• Length: 225 bp

>AT129598 NZ_CP041793:c2877993-2877769 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Structures

Toxin

• AlphaFold DB: G0TQ08

Antitoxin

• AlphaFold DB: G0TQ09