Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2876420..2877051 Replicon chromosome
Accession NZ_CP041792
Organism Mycobacterium tuberculosis strain SEA15230P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ28
Locus tag FPK18_RS13350 Protein ID WP_003413174.1
Coordinates 2876674..2877051 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag FPK18_RS13345 Protein ID WP_003413167.1
Coordinates 2876420..2876677 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK18_RS13310 2871678..2871992 + 315 WP_009937839.1 hypothetical protein -
FPK18_RS13315 2872288..2873499 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
FPK18_RS13320 2873626..2874285 + 660 WP_003900846.1 LppA family lipoprotein -
FPK18_RS13325 2874282..2874941 + 660 WP_003900847.1 hypothetical protein -
FPK18_RS13330 2874938..2875600 + 663 WP_003900848.1 hypothetical protein -
FPK18_RS13335 2875597..2875875 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
FPK18_RS13340 2875968..2876381 + 414 WP_003413164.1 PIN domain nuclease -
FPK18_RS13345 2876420..2876677 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
FPK18_RS13350 2876674..2877051 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin Toxin
FPK18_RS13355 2877067..2877441 - 375 WP_003413177.1 hypothetical protein -
FPK18_RS13360 2877541..2877936 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
FPK18_RS13365 2877933..2878178 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
FPK18_RS13370 2878589..2879008 - 420 WP_003413190.1 A24 family peptidase -
FPK18_RS13375 2879020..2879829 - 810 WP_003413193.1 shikimate dehydrogenase -
FPK18_RS13380 2879826..2881079 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
FPK18_RS13385 2881072..2881584 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13728.72 Da        Isoelectric Point: 4.4687

>T129540 WP_003413174.1 NZ_CP041792:2876674-2877051 [Mycobacterium tuberculosis]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY

Download         Length: 378 bp

>T129540 NZ_CP041792:2876674-2877051 [Mycobacterium tuberculosis]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT129540 WP_003413167.1 NZ_CP041792:2876420-2876677 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT129540 NZ_CP041792:2876420-2876677 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ28

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References