Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2412420..2412949 Replicon chromosome
Accession NZ_CP041792
Organism Mycobacterium tuberculosis strain SEA15230P6C4

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag FPK18_RS11180 Protein ID WP_003411124.1
Coordinates 2412420..2412737 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag FPK18_RS11185 Protein ID WP_003411127.1
Coordinates 2412734..2412949 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK18_RS11150 2407615..2408691 + 1077 WP_003904789.1 hypothetical protein -
FPK18_RS11155 2408688..2408969 + 282 WP_003411112.1 hypothetical protein -
FPK18_RS11160 2409005..2410078 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
FPK18_RS11165 2410083..2410613 - 531 WP_003904790.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
FPK18_RS11170 2410661..2412007 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
FPK18_RS11180 2412420..2412737 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FPK18_RS11185 2412734..2412949 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
FPK18_RS11190 2413204..2414262 + 1059 WP_003904791.1 hypothetical protein -
FPK18_RS11195 2414392..2414748 - 357 WP_003411130.1 hypothetical protein -
FPK18_RS11200 2414843..2415625 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
FPK18_RS11205 2415893..2416183 - 291 WP_003900476.1 YggT family protein -
FPK18_RS11210 2416345..2417001 - 657 WP_003411133.1 cell division protein SepF -
FPK18_RS11215 2417067..2417843 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T129536 WP_003411124.1 NZ_CP041792:c2412737-2412420 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T129536 NZ_CP041792:c2412737-2412420 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT129536 WP_003411127.1 NZ_CP041792:c2412949-2412734 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT129536 NZ_CP041792:c2412949-2412734 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References