Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2211835..2212379 Replicon chromosome
Accession NZ_CP041792
Organism Mycobacterium tuberculosis strain SEA15230P6C4

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag FPK18_RS10200 Protein ID WP_003409896.1
Coordinates 2211835..2212131 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag FPK18_RS10205 Protein ID WP_003409899.1
Coordinates 2212128..2212379 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK18_RS10145 2206868..2207218 - 351 WP_003409871.1 hypothetical protein -
FPK18_RS10150 2207229..2208131 - 903 WP_003409874.1 hypothetical protein -
FPK18_RS10155 2208152..2208343 - 192 WP_003409876.1 hypothetical protein -
FPK18_RS10160 2208344..2208640 - 297 WP_003409877.1 hypothetical protein -
FPK18_RS10165 2208880..2209095 + 216 WP_003409878.1 antitoxin -
FPK18_RS10170 2209092..2209403 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
FPK18_RS10175 2209377..2209898 - 522 WP_003904745.1 hypothetical protein -
FPK18_RS10180 2209873..2210250 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
FPK18_RS10185 2210292..2210741 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
FPK18_RS10190 2210738..2211283 + 546 WP_003409891.1 SecB-like chaperone -
FPK18_RS10195 2211172..2211786 - 615 WP_003901296.1 hypothetical protein -
FPK18_RS10200 2211835..2212131 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FPK18_RS10205 2212128..2212379 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FPK18_RS10210 2212366..2212860 + 495 WP_003899099.1 hypothetical protein -
FPK18_RS10215 2213020..2213427 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
FPK18_RS10220 2213431..2213703 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPK18_RS10225 2213736..2214956 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
FPK18_RS10230 2215855..2216652 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-93)

Antitoxin

(2-80)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T129528 WP_003409896.1 NZ_CP041792:c2212131-2211835 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T129528 NZ_CP041792:c2212131-2211835 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT129528 WP_003409899.1 NZ_CP041792:c2212379-2212128 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT129528 NZ_CP041792:c2212379-2212128 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TLU9


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References