Detailed information of TA system TA129518

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1386861..1387549
• Replicon: chromosome
• Accession: NZ_CP041792
• Organism: Mycobacterium tuberculosis strain SEA15230P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: FPK18_RS06490
• Protein ID: WP_003406304.1
• Coordinates: 1387118..1387549 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: FPK18_RS06485
• Protein ID: WP_003406302.1
• Coordinates: 1386861..1387121 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPK18_RS06465	1382438..1383262	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
FPK18_RS06470	1383267..1384448	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
FPK18_RS06475	1384525..1385625	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
FPK18_RS06480	1385796..1386785	+	990	WP_031697153.1	malate dehydrogenase	-
FPK18_RS06485	1386861..1387121	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
FPK18_RS06490	1387118..1387549	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPK18_RS06495	1387572..1389260	-	1689	WP_003910308.1	PE family protein	-
FPK18_RS06500	1389440..1390300	+	861	WP_003903377.1	hypothetical protein	-
FPK18_RS06505	1390381..1391211	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
FPK18_RS06510	1391268..1391561	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
FPK18_RS06515	1391558..1391827	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T129518 WP_003406304.1 NZ_CP041792:1387118-1387549 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T129518 NZ_CP041792:1387118-1387549 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT129518 WP_003406302.1 NZ_CP041792:1386861-1387121 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT129518 NZ_CP041792:1386861-1387121 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6