Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/AbrB(antitoxin)
Location 701706..702352 Replicon chromosome
Accession NZ_CP041792
Organism Mycobacterium tuberculosis strain SEA15230P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ88
Locus tag FPK18_RS03125 Protein ID WP_003403137.1
Coordinates 701706..702119 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ89
Locus tag FPK18_RS03130 Protein ID WP_003403139.1
Coordinates 702116..702352 (-) Length 79 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK18_RS03105 697789..699339 + 1551 WP_003403119.1 MCE family protein -
FPK18_RS03110 699391..699783 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 -
FPK18_RS03115 699780..700037 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 -
FPK18_RS03120 700220..701455 - 1236 WP_003403128.1 ATP-binding protein -
FPK18_RS03125 701706..702119 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin Toxin
FPK18_RS03130 702116..702352 - 237 WP_003403139.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FPK18_RS03135 702456..702962 - 507 WP_003900973.1 two component system sensor kinase HK1 -
FPK18_RS03140 703076..703606 - 531 WP_003917320.1 two component system sensor kinase HK2 -
FPK18_RS03145 703590..704351 - 762 WP_003904438.1 two-component system response regulator TcrA -
FPK18_RS03150 704408..704719 + 312 WP_003403164.1 hypothetical protein -
FPK18_RS03155 704791..705741 + 951 WP_003907436.1 DUF1259 domain-containing protein -
FPK18_RS03160 705982..706566 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
FPK18_RS03165 706568..707278 + 711 Protein_627 transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-126)

Antitoxin

(3-43)


Sequences


Toxin        


Download         Length: 138 a.a.        Molecular weight: 14786.14 Da        Isoelectric Point: 8.1405

>T129503 WP_003403137.1 NZ_CP041792:c702119-701706 [Mycobacterium tuberculosis]
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA

Download         Length: 414 bp

>T129503 NZ_CP041792:c702119-701706 [Mycobacterium tuberculosis]
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGACACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8212.41 Da        Isoelectric Point: 5.0351

>AT129503 WP_003403139.1 NZ_CP041792:c702352-702116 [Mycobacterium tuberculosis]
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK

Download         Length: 237 bp

>AT129503 NZ_CP041792:c702352-702116 [Mycobacterium tuberculosis]
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TQ88


Antitoxin

Source ID Structure
AlphaFold DB G0TQ89

References